Evidence map›Paper›PMID 25621200›Full record

ArticleCurrent opinion in chemical engineering2015

Intelligent Nanoparticles for Advanced Drug Delivery in Cancer Treatment.

David S Spencer, Amey S Puranik, Nicholas A Peppas

Abstract read
In one paragraph

Article in Current opinion in chemical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. A smart OActa pharmaceutica Sinica. B · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Biodegradable cationic nanogels with tunable size, swelling and pKInternational journal of pharmaceutics · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Recent advances in nanoengineering cellulose for cargo delivery.Journal of controlled release : official journal of the Controlled Release Society · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David S SpencerDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Amey S PuranikDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Nicholas A PeppasDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA ; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA ; College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA ; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, 78712, USA.

Funding

pH Sensitive Complex Hydrogels for Protein Drug ReleaseR01EB000246 · NIBIB · UNIVERSITY OF TEXAS AUSTIN · PI LOWMAN, ANTHONY M, PEPPAS, NICHOLAS A · 2002 to 2014
$3.8M
NIBIB NIH HHS R01 EB000246
6 · The paper itself

Abstract

Treatment of cancer using nanoparticle-based approaches relies on the rational design of carriers with respect to size, charge, and surface properties. Polymer-based nanomaterials, inorganic materials such as gold, iron oxide, and silica as well as carbon based materials such as carbon nanotubes and graphene are being explored extensively for cancer therapy. The challenges associated with the delivery of these nanoparticles depend greatly on the type of cancer and stage of development. This review highlights design considerations to develop nanoparticle-based approaches for overcoming physiological hurdles in cancer treatment, as well as emerging research in engineering advanced delivery systems for the treatment of primary, metastatic, and multidrug resistant cancers. A growing understanding of cancer biology will continue to foster development of intelligent nanoparticle-based therapeutics that take into account diverse physiological contexts of changing disease states to improve treatment outcomes.

Indexed as

cancerdrug deliveryhydrogelsnanoparticles

Identifiers

PMID25621200
PMCPMC4303181

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.