Evidence map›Paper›PMID 25621153›Full record

ReviewPulmonary circulation2014

Biomechanics of the right ventricle in health and disease (2013 Grover Conference series).

Robert Naeije, Serge Brimioulle, Laurence Dewachter

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pulmonary circulation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03048032 (Diagnostic and Prognostic Value of Cardiac Biomarkers and Echocardiography for Patients Hospitalized Due to Acute Dyspnea), which is not on this map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03048032 completednot on this mapstarted 2015, after this paper: background citation

Diagnostic and Prognostic Value of Cardiac Biomarkers and Echocardiography for Patients Hospitalized Due to Acute Dyspnea: Prospective Observational Multicenter Cohort Study

TypeobservationalSponsorVilnius UniversityRan2015 to 2018Enrolled1,566ConditionsAcute Heart FailureArmsBlood sampling, Echocardiography exam
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 131 citations in OpenAlex.

  1. A novel single-beat approach to assess right ventricular systolic function.Journal of applied physiology (Bethesda, Md. : 1985) · 2018
    Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Right ventricular dysfunction in structural tricuspid interventions.European heart journal. Imaging methods and practice · 2025
    Review
  7. Review
  8. Article
  9. Right heart reverse remodeling:International journal of cardiology. Congenital heart disease · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. The tricuspid annular plane systolic excursion/PASP ratio's accuracy and validity in assessing the right ventricular function: A narrative review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert NaeijeDepartment of Physiology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium.
Serge BrimioulleDepartment of Physiology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium.
Laurence DewachterDepartment of Physiology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Right ventricular (RV) function is a major determinant of the symptomatology and outcome in pulmonary hypertension. The normal RV is a thin-walled flow generator able to accommodate large changes in venous return but unable to maintain flow output in the presence of a brisk increase in pulmonary artery pressure. The RV chronically exposed to pulmonary hypertension undergoes hypertrophic changes and an increase in contractility, allowing for preserved flow output in response to peripheral demand. Failure of systolic function adaptation (homeometric adaptation, described by Anrep's law of the heart) results in increased dimensions (heterometric adaptation; Starling's law of the heart), with a negative effect on diastolic ventricular interactions, limitation of exercise capacity, and vascular congestion. Ventricular function is described by pressure-volume relationships. The gold standard of systolic function is maximum elastance (E max), or the maximal value of the ratio of pressure to volume. This value is not immediately sensitive to changes in loading conditions. The gold standard of afterload is arterial elastance (E a), defined by the ratio of pressure at E max to stroke volume. The optimal coupling of ventricular function to the arterial circulation occurs at an E max/E a ratio between 1.5 and 2. Patients with severe pulmonary hypertension present with an increased E max, a trend toward decreased E max/E a, and increased RV dimensions, along with progression of the pulmonary vascular disease, systemic factors, and left ventricular function. The molecular mechanisms of RV systolic failure are currently being investigated. It is important to refer biological findings to sound measurements of function. Surrogates for E max and E a are being developed through bedside imaging techniques.

Indexed as

afterloadarterial elastanceend-systolic elastancemaximum elastancepreloadpulmonary hypertensionright ventricle

Identifiers

PMID25621153
PMCPMC4278599
OpenAlexW2044032429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.