ArticleWorld journal of stem cells2015
Regulated genes in mesenchymal stem cells and gastric cancer.
Article in World journal of stem cells, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Adverse Outcome Pathway 298: Increase in Reactive Oxygen Species Leading to Human Treatment-Resistant Gastric Cancer.Cancers · 2026Article
- FASN multi-omic characterization reveals metabolic heterogeneity in pancreatic and prostate adenocarcinoma.Journal of translational medicine · 2023Article
- RGS1 serves as an antitumor target to inhibit proliferation of NICN87-DR cells and tumor growth in the gastric cancer mouse model.Turkish journal of biology = Turk biyoloji dergisi · 2022Article
- Identification of key miRNA-gene pairs in gastric cancer through integrated analysis of mRNA and miRNA microarray.American journal of translational research · 2021Article
- Identification of a Four-Gene-Based SERM Signature for Prognostic and Drug Sensitivity Prediction in Gastric Cancer.Frontiers in oncology · 2021Article
- Bone marrow mesenchymal stem cells interact with head and neck squamous cell carcinoma cells to promote cancer progression and drug resistance.Neoplasia (New York, N.Y.) · 2021Article
- Review
- Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies.Frontiers in pharmacology · 2020Review
- Mesenchymal Stem Cells Induce Epithelial to Mesenchymal Transition in Colon Cancer Cells through Direct Cell-to-Cell Contact.Neoplasia (New York, N.Y.) · 2017Article
- Prognostic significance of tumor budding and single cell invasion in gastric adenocarcinoma.OncoTargets and therapy · 2017Article
- Gene expression and pathway analysis ofWorld journal of stem cells · 2016Article
- Signaling involved in stem cell reprogramming and differentiation.World journal of stem cells · 2015Article
- Evaluation of Tumor Budding in Predicting Survival for Gastric Carcinoma Patients in Vietnam.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
aimTo investigate the genes regulated in mesenchymal stem cells (MSCs) and diffuse-type gastric cancer (GC), gene expression was analyzed.
methodsGene expression of MSCs and diffuse-type GC cells were analyzed by microarray. Genes related to stem cells, cancer and the epithelial-mesenchymal transition (EMT) were extracted from human gene lists using Gene Ontology and reference information. Gene panels were generated, and messenger RNA gene expression in MSCs and diffuse-type GC cells was analyzed. Cluster analysis was performed using the NCSS software.
resultsThe gene expression of regulator of G-protein signaling 1 (RGS1) was up-regulated in diffuse-type GC cells compared with MSCs. A panel of stem-cell related genes and genes involved in cancer or the EMT were examined. Stem-cell related genes, such as growth arrest-specific 6, musashi RNA-binding protein 2 and hairy and enhancer of split 1 (Drosophila), NOTCH family genes and Notch ligands, such as delta-like 1 (Drosophila) and Jagged 2, were regulated.
conclusionExpression of RGS1 is up-regulated, and genes related to stem cells and NOTCH signaling are altered in diffuse-type GC compared with MSCs.
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