ReviewWorld journal of stem cells2015
Stem cell therapy for retinal diseases.
Review in World journal of stem cells, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Establishment of human embryonic stem cell line expressing EGFP reporter driven by human RAX promoter for evaluation of retinal progenitor cell potency.In vitro cellular & developmental biology. Animal · 2026Article
- Stem cell-based therapies for inherited retinal diseases - Translational advances and clinical evidence: A review.Biomolecules & biomedicine · 2026Review
- Retinal Organoids and Retinal Prostheses: An Overview.International journal of molecular sciences · 2022Review
- A phase I clinical trial of human embryonic stem cell-derived retinal pigment epithelial cells for early-stage Stargardt macular degeneration: 5-years' follow-up.Cell proliferation · 2021Article
- Review
- In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell-Induced Photoreceptor Survival.Proteomics · 2019Article
- GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell.Cell death discovery · 2019Article
- Overexpression of MiR-183/96/182 Triggers Retina-Like Fate in Human Bone Marrow-Derived Mesenchymal Stem Cells (hBMSCs) in Culture.Journal of ophthalmology · 2019Article
- Differentiation of retinal ganglion cells from induced pluripotent stem cells: a review.International journal of ophthalmology · 2019Review
- Isolation and characterization of olfactory ecto-mesenchymal stem cells from eight mammalian genera.BMC veterinary research · 2018Article
- Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration.Stem cells international · 2018Review
- Comparative proteomic analysis of human embryonic stem cell-derived and primary human retinal pigment epithelium.Scientific reports · 2017Article
- Compound anisodine affects the proliferation and calcium overload of hypoxia-induced rat retinal progenitor cells and brain neural stem cells via the p-ERK1/2/HIF-1α/VEGF pathway.Experimental and therapeutic medicine · 2017Article
- Cord blood cell-derived iPSCs as a new candidate for chondrogenic differentiation and cartilage regeneration.Stem cell research & therapy · 2017Article
- A basis for comparison: sensitive authentication of stem cell derived RPE using physiological responses of intact RPE monolayers.Stem cell and translational investigation · 2017Article
- The Treatment Paradigm for the Implantable Miniature Telescope.Ophthalmology and therapy · 2016Review
- Pluripotent stem cells progressing to the clinic.Nature reviews. Molecular cell biology · 2016Review
- Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy.Oncotarget · 2016Article
- Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration.Molecular vision · 2016Article
- Age-related macular degeneration: a review of current therapies and new treatments.Arquivos brasileiros de oftalmologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, we discuss about current knowledge about stem cell (SC) therapy in the treatment of retinal degeneration. Both human embryonic stem cell and induced pluripotent stem cell has been growth in culture for a long time, and started to be explored in the treatment of blinding conditions. The Food and Drug Administration, recently, has granted clinical trials using SC retinal therapy to treat complex disorders, as Stargardt's dystrophy, and patients with geographic atrophy, providing good outcomes. This study's intent is to overview the critical regeneration of the subretinal anatomy through retinal pigment epithelium transplantation, with the goal of reestablish important pathways from the retina to the occipital cortex of the brain, as well as the differentiation from pluripotent quiescent SC to adult retina, and its relationship with a primary retinal injury, different techniques of transplantation, management of immune rejection and tumorigenicity, its potential application in improving patients' vision, and, finally, approaching future directions and challenges for the treatment of several conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.