Evidence map›Paper›PMID 25621105›Full record

ReviewWorld journal of stem cells2015

Current progress in use of adipose derived stem cells in peripheral nerve regeneration.

Shomari Dl Zack-Williams, Peter E Butler, Deepak M Kalaskar

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of stem cells, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 80 citations in OpenAlex.

  1. Fat grafting in soleal sling syndrome: a retrospective case series.Case reports in plastic surgery & hand surgery · 2026
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  14. Adipose Tissue Uses in Peripheral Nerve Surgery.International journal of molecular sciences · 2022
    Review
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shomari Dl Zack-WilliamsShomari DL Zack-Williams, Peter E Butler, Deepak M Kalaskar, Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, WC1E 6BT London, United Kingdom.
Peter E ButlerShomari DL Zack-Williams, Peter E Butler, Deepak M Kalaskar, Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, WC1E 6BT London, United Kingdom.
Deepak M KalaskarShomari DL Zack-Williams, Peter E Butler, Deepak M Kalaskar, Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, WC1E 6BT London, United Kingdom.
London Centre for Nanotechnology · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlike central nervous system neurons; those in the peripheral nervous system have the potential for full regeneration after injury. Following injury, recovery is controlled by schwann cells which replicate and modulate the subsequent immune response. The level of nerve recovery is strongly linked to the severity of the initial injury despite the significant advancements in imaging and surgical techniques. Multiple experimental models have been used with varying successes to augment the natural regenerative processes which occur following nerve injury. Stem cell therapy in peripheral nerve injury may be an important future intervention to improve the best attainable clinical results. In particular adipose derived stem cells (ADSCs) are multipotent mesenchymal stem cells similar to bone marrow derived stem cells, which are thought to have neurotrophic properties and the ability to differentiate into multiple lineages. They are ubiquitous within adipose tissue; they can form many structures resembling the mature adult peripheral nervous system. Following early in vitro work; multiple small and large animal in vivo models have been used in conjunction with conduits, autografts and allografts to successfully bridge the peripheral nerve gap. Some of the ADSC related neuroprotective and regenerative properties have been elucidated however much work remains before a model can be used successfully in human peripheral nerve injury (PNI). This review aims to provide a detailed overview of progress made in the use of ADSC in PNI, with discussion on the role of a tissue engineered approach for PNI repair.

Indexed as

Adipose derived stem cellsCell based therapiesPeripheral nerve injuryStem cells

Identifiers

PMID25621105
PMCPMC4300936
OpenAlexW2109411881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.