Evidence map›Paper›PMID 25621035›Full record

ArticleOncology letters2015

Stromal myofibroblasts in potentially malignant and malignant lesions of the oral cavity.

Priscila Campioni Rodrigues, Márcia Cristina DA Costa Miguel, Sibele Nascimento DE Aquino, Felipe Paiva Fonseca, Alan Roger Dos Santos Silva, Adriana Franco Paes Leme, Ricardo D Coletta

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Priscila Campioni RodriguesDepartment of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, São Paulo 13414-018, Brazil.
Márcia Cristina DA Costa MiguelDepartment of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, São Paulo 13414-018, Brazil ; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59072-970, Brazil.
Sibele Nascimento DE AquinoDepartment of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, São Paulo 13414-018, Brazil.
Felipe Paiva FonsecaDepartment of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, São Paulo 13414-018, Brazil.
Alan Roger Dos Santos SilvaDepartment of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, São Paulo 13414-018, Brazil.
Adriana Franco Paes LemeBrazilian Biosciences National Laboratory, National Center for Research in Energy and Materials, Campinas, São Paulo 13083-970, Brazil.
Ricardo D ColettaDepartment of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, São Paulo 13414-018, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRBrazilian Biosciences National Laboratory · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have demonstrated that myofibroblasts in the adjacent stroma are involved in the development and progression of malignant tumors. The aim of this study was to investigate the involvement of myofibroblasts in the progression of oral squamous cell carcinomas (OSCCs) by determining myofibroblast density in potentially malignant and malignant oral lesions. A total of 69 potentially malignant oral lesions (leukoplakias with mild, moderate or severe dysplasia), 90 OSCCs (well-, moderately and poorly differentiated), eight oral verrucous carcinomas and 29 fibrous hyperplasias were examined for the presence of myofibroblasts using immunohistochemical detection of isoform α of smooth muscle actin. Myofibroblasts were not identified in the adjacent stroma of fibrous hyperplasias and potentially malignant oral lesions, whereas 59.8% of the oral carcinomas exhibited myofibroblasts in various densities. The density was significantly higher in moderately and poorly differentiated OSCCs when compared with well-differentiated tumors (P=0.04 and P=0.007, respectively). In verrucous carcinomas, the specific variant of well-differentiated OSCC, stromal myofibroblasts were not detected. The results of the present study demonstrated that immunodetection of myofibroblasts does not aid with the determination of the malignant transformation potential of oral dysplasias, although moderately and poorly differentiated tumors exhibited a significantly higher density of myofibroblasts. The results reinforce the hypothesis that myofibroblasts may contribute to oral tumorigenesis, indicating that verification and monitoring of such may serve as a putative marker of OSCC behavior.

Indexed as

myofibroblastoral squamous cell carcinomaoral verrucous carcinomapotentially malignant oral lesions

Identifiers

PMID25621035
PMCPMC4301498
OpenAlexW2046164282

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.