ArticleKorean Journal of Spine2014
Influence of alendronate and endplate degeneration to single level posterior lumbar spinal interbody fusion.
Article in Korean Journal of Spine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Postoperative bisphosphonate do not significantly alter the fusion rate after lumbar spinal fusion: a meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis.Drug design, development and therapy · 2018Pooled it
- Osteoporosis and adult spinal deformity-a review for spinal surgeons by the SRS adult spinal deformity task force on senescence.Spine deformity · 2026Review
- A new modic changes classification and its impact on posterior lumbar interbody fusion.BMC musculoskeletal disorders · 2025Article
- Osteoporosis in Adult Patients Undergoing Spinal Reconstructive Surgery: Associated Complications and Management.Global spine journal · 2025Article
- Personalized Approaches to Spine Surgery.International journal of spine surgery · 2024Article
- Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion.Acta orthopaedica et traumatologica turcica · 2024Article
- Evaluating osteoporosis and bone quality in the aging spine: modern considerations for surgical management in the geriatric population.GeroScience · 2024Review
- Effects of anti-osteoporosis treatment in elderly patients with osteoporosis and lumbar discectomy and fusion.Journal of back and musculoskeletal rehabilitation · 2024Article
- Patient Optimization for the Prevention of Proximal Junctional Kyphosis.International journal of spine surgery · 2023Article
- Does Preoperative Modic Changes Influence the Short-term Fusion Rate of Single Level Transforaminal Lumbar Interbody Fusion?-a Matched-pair Case Control Study.Orthopaedic surgery · 2023Article
- Medical optimization of osteoporosis for adult spinal deformity surgery: a state-of-the-art evidence-based review of current pharmacotherapy.Spine deformity · 2023Review
- Timing of osteoporosis therapies following fracture: the current status.Therapeutic advances in endocrinology and metabolism · 2022Review
- Clinical and radiographic outcomes of hybrid graft in patients with Modic changes undergoing transforaminal lumbar interbody fusion.Journal of orthopaedic surgery and research · 2021Article
- Bisphosphonate's and Intermittent Parathyroid Hormone's Effect on Human Spinal Fusion: A Systematic Review of the Literature.Asian spine journal · 2017Review
- A Systematic Review of Treatment Strategies for Degenerative Lumbar Spine Fusion Surgery in Patients With Osteoporosis.Geriatric orthopaedic surgery & rehabilitation · 2016Article
- Atypical Complete Femoral Fractures Associated with Bisphosphonate Use or Not Associated with Bisphosphonate Use: Is There a Difference?BioMed research international · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveUsing alendronate after spinal fusion is a controversial issue due to the inhibition of osteoclast mediated bone resorption. In addition, there are an increasing number of reports that the endplate degeneration influences the lumbar spinal fusion. The object of this retrospective controlled study was to evaluate how the endplate degeneration and the bisphosphonate medication influence the spinal fusion through radiographic evaluation.
methodsIn this study, 44 patients who underwent single-level posterior lumbar interbody fusion (PLIF) using cage were examined from April 2007 to March 2009. All patients had been diagnosed as osteoporosis and would be recommended for alendronate medication. Endplate degeneration is categorized by the Modic changes. The solid fusion is defined if there was bridging bone between the vertebral bodies, either within or external to the cage on the plain X-ray and if there is less than 5° of angular difference in dynamic X-ray.
resultsIn alendronate group, fusion was achieved in 66.7% compared to 73.9% in control group (no medication). Alendronate did not influence the fusion rate of PLIF. However, there was the statistical difference of fusion rate between the endplate degeneration group and the group without endplate degeneration. A total of 52.4% of fusion rate was seen in the endplate degeneration group compared to 91.3% in the group without endplate degeneration. The endplate degeneration suppresses the fusion process of PLIF.
conclusionAlendronate does not influence the fusion process in osteoporotic patients. The endplate degeneration decreases the fusion rate.
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