ArticleFrontiers in microbiology2014
Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity.Cell reports · 2025Article
- Interleukin-37 in respiratory diseases: molecular mechanisms and immune modulation.Frontiers in immunology · 2025Review
- Non-canonical activation of IRE1α duringbioRxiv : the preprint server for biology · 2024Article
- Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology.Oxford open immunology · 2024Review
- Interleukin-37 exacerbates experimental colitis in an intestinal microbiome-dependent fashion.Theranostics · 2022Article
- The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain ofFrontiers in immunology · 2022Article
- The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.FEMS microbiology reviews · 2021Review
- Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus.Frontiers in microbiology · 2021Review
- Current Understanding of IL-37 in Human Health and Disease.Frontiers in immunology · 2021Review
- In vitro immune responses of human PBMCs against Candida albicans reveals fungal and leucocyte phenotypes associated with fungal persistence.Scientific reports · 2020Article
- IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.Nature immunology · 2019Article
- The Role of Interleukin-1 cytokine family (IL-1β, IL-37) and interleukin-12 cytokine family (IL-12, IL-35) in eumycetoma infection pathogenesis.PLoS neglected tropical diseases · 2019Article
- Role for nuclear interleukin-37 in the suppression of innate immunity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake.International journal of molecular sciences · 2018Article
- Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases.BioMed research international · 2018Review
- IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia.Journal of innate immunity · 2017Article
- Tuberculosis-sensitized monocytes sustain immune response of interleukin-37.Molecular immunology · 2016Article
- Suppression of innate inflammation and immunity by interleukin-37.European journal of immunology · 2016Review
- Interleukin-37 Expression Is Increased in Chronic HIV-1-Infected Individuals and Is Associated with Inflammation and the Size of the Total Viral Reservoir.Molecular medicine (Cambridge, Mass.) · 2015Article
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Authors and funding
7 authors at 1 institution in 2 countries.
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Abstract
The effect of the anti-inflammatory cytokine interleukin-37 (IL-37) on host defense against Candida infections remains unknown. We assessed the role of IL-37 in a murine model of disseminated candidiasis using mice transgenic for human IL-37 (hIL-37Tg). Upon exposure to Candida albicans pseudohyphae, macrophages from hIL-37Tg mice release 39% less TNFα compared to cells from wild-type (WT) mice (p = 0.01). In vivo, hIL-37Tg mice displayed a decreased capacity to recruit neutrophils to the site of infection. These defects were associated with increased mortality and organ fungal growth in hIL-37Tg compared to WT mice. We conclude that IL-37 interferes with the innate protective anti-Candida host response by reducing the production of proinflammatory cytokines and suppressing neutrophil recruitment in response to Candida, resulting in an increased susceptibility to disseminated candidiasis.
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