ArticleFrontiers in cellular neuroscience2014
Subthreshold membrane currents confer distinct tuning properties that enable neurons to encode the integral or derivative of their input.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
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- Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axons.Proceedings. Biological sciences · 2025Review
- KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Electrophysiological Alterations Driving Pain-Associated Spontaneous Activity in Human Sensory Neuron Somata Parallel Alterations Described in Spontaneously Active Rodent Nociceptors.The journal of pain · 2022Article
- Imbalanced Subthreshold Currents Following Sepsis and Chemotherapy: A Shared Mechanism Offering a New Therapeutic Target?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
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- The century-old picture of a nerve spike is wrong: filaments fire, before membrane.Communicative & integrative biology · 2022Review
- Kv1 channels regulate variations in spike patterning and temporal reliability in the avian cochlear nucleus angularis.Journal of neurophysiology · 2022Article
- A spiking neural program for sensorimotor control during foraging in flying insects.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Propriospinal Neurons of L3-L4 Segments Involved in Control of the Rat External Urethral Sphincter.Neuroscience · 2020Article
- From Topological Analyses to Functional Modeling: The Case of Hippocampus.Frontiers in computational neuroscience · 2020Article
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- Differentially synchronized spiking enables multiplexed neural coding.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Selective attenuation of Ether-a-go-go related KeLife · 2019Article
- Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons.Scientific reports · 2019Article
- Using dynamic clamp to quantify pathological changes in the excitability of primary somatosensory neurons.The Journal of physiology · 2018Article
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5 authors.
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Abstract
Neurons rely on action potentials, or spikes, to encode information. But spikes can encode different stimulus features in different neurons. We show here through simulations and experiments how neurons encode the integral or derivative of their input based on the distinct tuning properties conferred upon them by subthreshold currents. Slow-activating subthreshold inward (depolarizing) current mediates positive feedback control of subthreshold voltage, sustaining depolarization and allowing the neuron to spike on the basis of its integrated stimulus waveform. Slow-activating subthreshold outward (hyperpolarizing) current mediates negative feedback control of subthreshold voltage, truncating depolarization and forcing the neuron to spike on the basis of its differentiated stimulus waveform. Depending on its direction, slow-activating subthreshold current cooperates or competes with fast-activating inward current during spike initiation. This explanation predicts that sensitivity to the rate of change of stimulus intensity differs qualitatively between integrators and differentiators. This was confirmed experimentally in spinal sensory neurons that naturally behave as specialized integrators or differentiators. Predicted sensitivity to different stimulus features was confirmed by covariance analysis. Integration and differentiation, which are themselves inverse operations, are thus shown to be implemented by the slow feedback mediated by oppositely directed subthreshold currents expressed in different neurons.
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