Evidence map›Paper›PMID 25620841›Full record

ArticleStatistical science : a review journal of the Institute of Mathematical Statistics2014

Interference and Sensitivity Analysis.

Tyler J VanderWeele, Eric J Tchetgen Tchetgen, M Elizabeth Halloran

Abstract read
In one paragraph

Article in Statistical science : a review journal of the Institute of Mathematical Statistics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Depicting patient-reported outcome measures within directed acyclic graphs: practice and implications for causal reasoning.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  4. Article
  5. Identification and estimation of causal peer effects using double negative controls for unmeasured network confounding.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Estimating the total treatment effect in randomized experiments with unknown network structure.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Tutorial on directed acyclic graphs.Journal of clinical epidemiology · 2022
    Article
  14. A Review of Spatial Causal Inference Methods for Environmental and Epidemiological Applications.International statistical review = Revue internationale de statistique · 2021
    Article
  15. Article
  16. Auto-G-Computation of Causal Effects on a Network.Journal of the American Statistical Association · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. The Relative Economy and Drug Overdose Deaths.Epidemiology (Cambridge, Mass.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tyler J VanderWeeleDepartments of Epidemiology and Biostatistics, Harvard School of Public Health, University of Washington.
Eric J Tchetgen TchetgenDepartments of Epidemiology and Biostatistics, Harvard School of Public Health, University of Washington.
M Elizabeth HalloranVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center and Department of Biostatistics, University of Washington.

Funding

Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANAGE, WILLIAM · 2009 to 2018
$26.4M
Methods for Evaluating Vaccine EfficacyR37AI032042 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HALLORAN, M ELIZABETH · 2010 to 2019
$5.1M
Causal Inference in Infectious Disease Prevention StudiesR01AI085073 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUDGENS, MICHAEL G · 2010 to 2024
$4.5M
Identification and Inference for Longitudinal Causal Mediation Analysis in HIVR01AI104459 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI SHPITSER, ILYA, VANDERWEELE, TYLER · 2013 to 2017
$2.0M
Semiparametric Methods for Gene-environment InteractionR01ES020337 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI TCHETGEN TCHETGEN, ERIC JOEL · 2012 to 2015
$1.4M
Theory and methods for sufficient cause interactionsR01ES017876 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI VANDERWEELE, TYLER · 2010 to 2014
$1.2M
Semiparametric Methods for Secondary Outcomes in Case-control StudiesR21ES019712 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI TCHETGEN TCHETGEN, ERIC JOEL · 2011 to 2012
$472k
A new Statistical Framework to Tame Selection Bias in Health SciencesR21AI113251 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI PHIRI, KELESITSE, TCHETGEN TCHETGEN, ERIC JOEL · 2014 to 2015
$449k
Causal Inference in Infectious Disease Prevention StudiesR37AI085073 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael G Hudgens · 2026 to 2026
$394k
NIAID NIH HHS R01 AI085073NIAID NIH HHS R01 AI104459NIAID NIH HHS R21 AI113251NIAID NIH HHS R37 AI032042NIAID NIH HHS R37 AI085073NIEHS NIH HHS R01 ES017876NIEHS NIH HHS R01 ES020337NIEHS NIH HHS R21 ES019712NIGMS NIH HHS U54 GM088558
6 · The paper itself

Abstract

Causal inference with interference is a rapidly growing area. The literature has begun to relax the "no-interference" assumption that the treatment received by one individual does not affect the outcomes of other individuals. In this paper we briefly review the literature on causal inference in the presence of interference when treatments have been randomized. We then consider settings in which causal effects in the presence of interference are not identified, either because randomization alone does not suffice for identification, or because treatment is not randomized and there may be unmeasured confounders of the treatment-outcome relationship. We develop sensitivity analysis techniques for these settings. We describe several sensitivity analysis techniques for the infectiousness effect which, in a vaccine trial, captures the effect of the vaccine of one person on protecting a second person from infection even if the first is infected. We also develop two sensitivity analysis techniques for causal effects in the presence of unmeasured confounding which generalize analogous techniques when interference is absent. These two techniques for unmeasured confounding are compared and contrasted.

Indexed as

Causal inferenceinfectiousness effectinterferencesensitivity analysisspillover effectstable unit treatment value assumptionvaccine trial

Identifiers

PMID25620841
PMCPMC4300555

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.