Evidence map›Paper›PMID 25620839›Full record

ArticleHeterocyclic communications2014

Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4.

Suazette Reid Mooring, Theresa Gaines, Zhongxing Liang, Hyunsuk Shim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heterocyclic communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Symmetrical bis-tertiary amines as novel CXCR4 inhibitors.European journal of medicinal chemistry · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Suazette Reid MooringDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Theresa GainesDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Zhongxing LiangDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA 30322, USA.
Hyunsuk ShimDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA 30322, USA.

Funding

Development of anti-CXCR4 compounds to block breast cancer metastasisR01CA165306 · NCI · EMORY UNIVERSITY · PI SHIM, HYUNSUK · 2012 to 2016
$1.7M
NCI NIH HHS R01 CA165306
6 · The paper itself

Abstract

A series of pyridine derivatives were synthesized as potential inhibitors of chemokine receptor type 4. This chemokine receptor has been linked to various disease pathways including HIV-1 proliferation, autoimmune disorders, inflammatory diseases, and cancer metastasis. The compounds were tested for activity using an affinity binding assay and an assay that tests the ability to inhibit cell invasion. Two hit compounds (

Indexed as

anti-canceranti-inflammatoryCXC chemokine receptor type 4 (CXCR4)pyridine derivatives

Identifiers

PMID25620839
PMCPMC4300533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.