ArticleTranslational stroke research2015
Increased Brain Perfusion Persists over the First Month of Life in Term Asphyxiated Newborns Treated with Hypothermia: Does it Reflect Activated Angiogenesis?
Article in Translational stroke research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Pathophysiology of Cerebral Hyperperfusion in Term Neonates With Hypoxic-Ischemic Encephalopathy: A Systematic Review for Future Research.Frontiers in pediatrics · 2021Pooled it
- MRI and proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy: a comprehensive imaging review.Japanese journal of radiology · 2026Review
- Elevated cerebral perfusion in neonatal encephalopathy is associated with neurodevelopmental impairments.Pediatric research · 2025Article
- Ultrasound Diagnosis and Near-Infrared Spectroscopy in the Study of Encephalopathy in Neonates Born under Asphyxia: Narrative Review.Children (Basel, Switzerland) · 2024Review
- Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke.Frontiers in cellular neuroscience · 2023Review
- Review
- Pericytes in Microvessels: From "Mural" Function to Brain and Retina Regeneration.International journal of molecular sciences · 2019Review
- Neuronal Circuit Activity during Neonatal Hypoxic-Ischemic Seizures in Mice.Annals of neurology · 2019Article
- Low b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest.Critical care (London, England) · 2018Article
- Brain Temperature Is Increased During the First Days of Life in Asphyxiated Newborns: Developing Brain Injury Despite Hypothermia Treatment.AJNR. American journal of neuroradiology · 2017Article
- Upregulation of cystathionine β-synthase and p70S6K/S6 in neonatal hypoxic ischemic brain injury.Brain pathology (Zurich, Switzerland) · 2017Article
- Pericytes in Brain Injury and Repair After Ischemic Stroke.Translational stroke research · 2017Review
- Article
- Impact of bronchopulmonary dysplasia on brain and retina.Biology open · 2016Article
- Does angiogenesis play a role in the establishment of mesial temporal lobe epilepsy?International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Article
- Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy.International journal of molecular sciences · 2015Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Many asphyxiated newborns still develop brain injury despite hypothermia therapy. The development of brain injury in these newborns has been related partly to brain perfusion abnormalities. The purposes of this study were to assess brain hyperperfusion over the first month of life in term asphyxiated newborns and to search for some histopathological clues indicating whether this hyperperfusion may be related to activated angiogenesis following asphyxia. In this prospective cohort study, regional cerebral blood flow was measured in term asphyxiated newborns treated with hypothermia around day 10 of life and around 1 month of life using magnetic resonance imaging (MRI) and arterial spin labeling. A total of 32 MRI scans were obtained from 24 term newborns. Asphyxiated newborns treated with hypothermia displayed an increased cerebral blood flow in the injured brain areas around day 10 of life and up to 1 month of life. In addition, we looked at the histopathological clues in a human asphyxiated newborn and in a rat model of neonatal encephalopathy. Vascular endothelial growth factor (VEGF) was expressed in the injured brain of an asphyxiated newborn treated with hypothermia in the first days of life and of rat pups 24-48 h after the hypoxic-ischemic event, and the endothelial cell count increased in the injured cortex of the pups 7 and 11 days after hypoxia-ischemia. Our data showed that the hyperperfusion measured by imaging persisted in the injured areas up to 1 month of life and that angiogenesis was activated in the injured brain of asphyxiated newborns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.