Evidence map›Paper›PMID 25620701›Full record

ArticleCell reports2015

Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake.

Courtney M Anderson, Melissa Kazantzis, Jinshan Wang, Subramaniam Venkatraman, Renata L S Goncalves, Casey L Quinlan, Ryan Ng, Martin Jastroch, Daniel I Benjamin, Biao Nie and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. The efficacy of coenzyme QJournal of cellular and molecular medicine · 2022
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Understanding coenzyme Q.Physiological reviews · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. New Insights on the Uptake and Trafficking of Coenzyme Q.Antioxidants (Basel, Switzerland) · 2023
    Review
  11. Coenzyme Q biochemistry and biosynthesis.Trends in biochemical sciences · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Nutrients · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Courtney M AndersonNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Melissa KazantzisNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Jinshan WangNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Subramaniam VenkatramanDepartment of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, CA 94720, USA.
Renata L S GoncalvesThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Casey L QuinlanThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Ryan NgThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Martin JastrochThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Daniel I BenjaminNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Biao NieNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Candice HerberNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
An-Angela Ngoc VanNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Michael J ParkNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Dawee YunNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Karen ChanNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Angela YuNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Peter VuongNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Maria FebbraioFaculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Daniel K NomuraNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Joseph L NapoliNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
Martin D BrandThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Andreas StahlNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA. Electronic address: astahl@berkeley.edu.
University of California, Berkeley · USBuck Institute for Research on Aging · USUniversity of Alberta · CA

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Training Program in Pediatric EndocrinologyT32DK007161 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian J Feldman, STEPHEN E GITELMAN · 1986 to 2026
$6.2M
Molecular Physiology of Liver Fatty Acid TransportersR01DK066336 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI STAHL, ANDREAS · 2004 to 2013
$2.7M
DEPENDENCE OF THERMOGENESIS AND BROWN ADIPOSE TISSUE FUNCTION ON FATP1 AND CD36R01DK089202 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI STAHL, ANDREAS · 2011 to 2015
$1.9M
Matrix assisted cell transplantation of brown fatR01DK101293 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, STAHL, ANDREAS · 2014 to 2017
$1.7M
Annotating the Role of Dysregulated Inositol Phosphate Metabolism in Malignant CaR01CA172667 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI NOMURA, DANIEL · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA172667NIDDK NIH HHS P30 DK026743NIDDK NIH HHS R01 DK066336NIDDK NIH HHS R01DK066336NIDDK NIH HHS R01 DK089202NIDDK NIH HHS R01DK089202NIDDK NIH HHS R01 DK101293NIDDK NIH HHS T32 DK007161
6 · The paper itself

Abstract

Brown adipose tissue (BAT) possesses the inherent ability to dissipate metabolic energy as heat through uncoupled mitochondrial respiration. An essential component of the mitochondrial electron transport chain is coenzyme Q (CoQ). While cells synthesize CoQ mostly endogenously, exogenous supplementation with CoQ has been successful as a therapy for patients with CoQ deficiency. However, which tissues depend on exogenous CoQ uptake as well as the mechanism by which CoQ is taken up by cells and the role of this process in BAT function are not well understood. Here, we report that the scavenger receptor CD36 drives the uptake of CoQ by BAT and is required for normal BAT function. BAT from mice lacking CD36 displays CoQ deficiency, impaired CoQ uptake, hypertrophy, altered lipid metabolism, mitochondrial dysfunction, and defective nonshivering thermogenesis. Together, these data reveal an important new role for the systemic transport of CoQ to BAT and its function in thermogenesis.

Indexed as

Adipose Tissue, BrownAnimalsAtaxiaCD36 AntigensChromatography, High Pressure LiquidMaleMiceMice, Inbred C57BLMitochondriaMitochondrial DiseasesMitochondrial ProteinsMuscle WeaknessOxidation-ReductionPalmitic AcidThermogenesisUbiquinoneCD36 AntigensMitochondrial ProteinsPalmitic AcidUbiquinone

Identifiers

PMID25620701
PMCPMC4318762
OpenAlexW2047193152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.