ArticleThe Annals of thoracic surgery2015
Relationship of single ventricle filling and preload to total cavopulmonary connection hemodynamics.
Article in The Annals of thoracic surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Deep learning for vessel segmentation and flow analysis to identify clusters associated with adverse outcomes in a fontan patient registry.Scientific reports · 2026Article
- Fontan Geometry and Hemodynamics Are Associated With Quality of Life in Adolescents and Young Adults.The Annals of thoracic surgery · 2022Article
- Society for Cardiovascular Magnetic Resonance/European Society of Cardiovascular Imaging/American Society of Echocardiography/Society for Pediatric Radiology/North American Society for Cardiovascular Imaging Guidelines for the use of cardiovascular magnetic resonance in pediatric congenital and acquired heart disease : Endorsed by The American Heart Association.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Review
- Society for Cardiovascular Magnetic Resonance/European Society of Cardiovascular Imaging/American Society of Echocardiography/Society for Pediatric Radiology/North American Society for Cardiovascular Imaging Guidelines for the Use of Cardiac Magnetic Resonance in Pediatric Congenital and Acquired Heart Disease: Endorsed by The American Heart Association.Circulation. Cardiovascular imaging · 2022Review
- Segmental assessment of blood flow efficiency in the total cavopulmonary connection using four-dimensional flow magnetic resonance imaging: vortical flow is associated with increased viscous energy loss rate.European heart journal open · 2021Article
- Role of surgeon intuition and computer-aided design in Fontan optimization: A computational fluid dynamics simulation study.The Journal of thoracic and cardiovascular surgery · 2020Article
- Virtual surgical planning, flow simulation, and 3-dimensional electrospinning of patient-specific grafts to optimize Fontan hemodynamics.The Journal of thoracic and cardiovascular surgery · 2018Article
- The Advantages of Viscous Dissipation Rate over Simplified Power Loss as a Fontan Hemodynamic Metric.Annals of biomedical engineering · 2018Article
- The Total Artificial Heart in End-Stage Congenital Heart Disease.Frontiers in physiology · 2017Review
- Computational modeling and engineering in pediatric and congenital heart disease.Current opinion in pediatrics · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundSingle ventricle lesions are associated with gradual attrition after surgical palliation with the total cavopulmonary connection (TCPC). Ventricular dysfunction is frequently noted, particularly impaired diastolic performance. This study seeks to relate TCPC hemodynamic energy losses to single ventricle volumes and filling characteristics.
methodsCardiac magnetic resonance (CMR) data were retrospectively analyzed for 30 single ventricle patients at an average age of 12.7 ± 4.8 years. Cine ventricular short-axis scans were semiautomatically segmented for all cardiac phases. Ventricular volumes, ejection fraction, peak filling rate, peak ejection rate, and time to peak filling were calculated. Corresponding patient-specific TCPC geometry was acquired from a stack of transverse CMR images; relevant flow rates were segmented from through-plane phase contrast CMR data at TCPC inlets and outlets. The TCPC indexed power loss was calculated from computational fluid dynamics simulations using a validated custom solver. Time-averaged flow conditions and rigid vessel walls were assumed in all cases. Pearson correlations were used to detect relationships between variables, with p less than 0.05 considered significant.
resultsVentricular end-diastolic (R = -0.48) and stroke volumes (R = -0.37) had significant negative correlations with the natural logarithm of a flow-independent measure of power loss. This power loss measure also had a significant positive relationship to time to peak filling rate (normalized to cycle time; R = 0.67).
conclusionsFlow-independent TCPC power loss is inversely related with ventricular end-diastolic and stroke volumes. Elevated power losses may contribute to impaired diastolic filling and limited preload reserve in single ventricle patients.
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