ArticleScientific reports2015
Uncertainty of prebiotic scenarios: the case of the non-enzymatic reverse tricarboxylic acid cycle.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The secret life of RNA and lipids.RNA biology · 2025Review
- Reactant Discovery with anACS earth & space chemistry · 2024Article
- The modular biochemical reaction network structure of cellular translation.NPJ systems biology and applications · 2023Article
- First principles reaction discovery: from the Schrodinger equation to experimental prediction for methane pyrolysis.Chemical science · 2023Article
- Automated Exploration of Prebiotic Chemical Reaction Space: Progress and Perspectives.Life (Basel, Switzerland) · 2021Review
- Thermodynamics of Potential CHO Metabolites in a Reducing Environment.Life (Basel, Switzerland) · 2021Article
- A thermodynamic atlas of carbon redox chemical space.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Prebiotic Reaction Networks in Water.Life (Basel, Switzerland) · 2020Review
- A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids.Nature chemistry · 2020Article
- Reactivity of Metabolic Intermediates and Cofactor Stability under Model Early Earth Conditions.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2020Article
- Environmental boundary conditions for the origin of life converge to an organo-sulfur metabolism.Nature ecology & evolution · 2019Article
- A Mixed Quantum Chemistry/Machine Learning Approach for the Fast and Accurate Prediction of Biochemical Redox Potentials and Its Large-Scale Application to 315 000 Redox Reactions.ACS central science · 2019Article
- Prebiotic chemistry in neutral/reduced-alkaline gas-liquid interfaces.Scientific reports · 2019Article
- Systems protobiology: origin of life in lipid catalytic networks.Journal of the Royal Society, Interface · 2018Review
- The Matter Simulation (R)evolution.ACS central science · 2018Review
- Efficient prediction of reaction paths through molecular graph and reaction network analysis.Chemical science · 2018Article
- Exploring astrobiology usingPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Article
- Computational exploration of the chemical structure space of possible reverse tricarboxylic acid cycle constituents.Scientific reports · 2017Article
- Metals promote sequences of the reverse Krebs cycle.Nature ecology & evolution · 2017Article
- Sulfate radicals enable a non-enzymatic Krebs cycle precursor.Nature ecology & evolution · 2017Article
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3 authors.
Funding
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Abstract
We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of this hypothesis due to the combinatorial aspect of the constituent chemical transformations. Our results suggest that a) rTCA cycle belongs to a degenerate optimum of auto-catalytic cycles, and b) the set of targets for investigations of the origin of the common metabolic core should be significantly extended.
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