ArticleDepression and anxiety2015
Potentiated processing of negative feedback in depression is attenuated by anhedonia.
Article in Depression and anxiety, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Brain rhythms of depression: A predictive processing perspective.Trends in neurosciences · 2026Review
- Investigating the relationship between gut microbiota and electrocortical signatures of feedback processing: an ERP study.Psychopharmacology · 2026Article
- Inefficient integration between effort and reward in anhedonia.Psychological medicine · 2026Article
- Differences in Consummatory but Not Anticipatory Reward Processing Predict Depressive Symptoms in Young Adult Women.Psychophysiology · 2025Article
- Subjective Experiences of Pregnancy, Delivery, and Nursing in Transgender Men and Non-Binary Individuals: A Qualitative Analysis of Gender and Mental Health Concerns.Archives of sexual behavior · 2024Article
- Positive valence system function and anhedonia in middle-aged and older adults at high suicide risk.Biological psychology · 2023Article
- Invasive Computational Psychiatry.Biological psychiatry · 2023Review
- Neural Correlates of Anhedonia in Major Depressive Disorder: Insights from Concurrent Analysis of Feedback-Related Negativity and Stimulus-Preceding Negativity.Neuropsychiatric disease and treatment · 2023Article
- Sensitivity to intrinsic rewards is domain general and related to mental health.Nature. Mental health · 2023Article
- Examining the neural correlates of error awareness in a large fMRI study.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Investigating mechanisms of cognitive control training: neural signatures of PASAT performance in depressed patients.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Win, lose, or draw: Examining salience, reward memory, and depression with the reward positivity.Psychophysiology · 2022Article
- Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress.PloS one · 2021Article
- Article
- Integrated phosphoproteomic and metabolomic profiling reveals perturbed pathways in the hippocampus of gut microbiota dysbiosis mice.Translational psychiatry · 2020Article
- Blunted Neural Reward Responsiveness in Children with Recent Suicidal Ideation.Clinical psychological science : a journal of the Association for Psychological Science · 2019Article
- Depressive symptoms bias the prediction-error enhancement of memory towards negative events in reinforcement learning.Psychopharmacology · 2019Article
- A neurophysiological measure of reward sensitivity and its association with anhedonia in psychiatrically healthy adolescents and young adults.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Article
- Understanding psychiatric disorder by capturing ecologically relevant features of learning and decision-making.Behavioural brain research · 2018Review
- Internal and external signal processing in patients with panic disorder: An event-related potential (ERP) study.PloS one · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAlthough cognitive theories of depression have postulated enhanced processing of negatively valenced information, previous EEG studies have shown both increased and reduced sensitivity for negative performance feedback in MDD. To reconcile these paradoxical findings, it has been speculated that sensitivity for negative feedback is potentiated in moderate MDD, but reduced in highly anhedonic subjects. The goal of this study was to test this hypothesis by analyzing the feedback-related negativity (FRN), frontomedial theta power (FMT), and source-localized anterior midcingulate cortex (aMCC) activity after negative feedback.
methodsFourteen unmedicated participants with Major Depressive Disorder (MDD) and 15 control participants performed a reinforcement learning task while 128-channel Electroencephalogram (EEG) was recorded. FRN, FMT, and LORETA source-localized aMCC activity after negative and positive feedback were compared between groups.
resultsThe MDD group showed higher FRN amplitudes and aMCC activation to negative feedback than controls. Moreover, aMCC activation to negative feedback was inversely related to self-reported anhedonia. In contrast, self-reported anxiety correlated with feedback-evoked frontomedial theta (FMT) within the depression group.
conclusionsThe present findings suggest that, among depressed and anxious individuals, enhanced processing of negative feedback occurs relatively early in the information processing stream. These results extend prior work and indicate that although moderate depression is associated with elevated sensitivity for negative feedback, high levels of anhedonia may attenuate this effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.