Evidence map›Paper›PMID 25620100›Full record

ReviewCurrent medicinal chemistry2015

Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network.

Tim Lekic, Damon Klebe, Roy Poblete, Paul R Krafft, William B Rolland, Jiping Tang, John H Zhang

Open access · greenAbstract readReview
In one paragraph

Review in Current medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Review
  6. Early-onset neonatal sepsis as a risk factor for peri-intraventricular hemorrhage in premature infants.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024
    Article
  7. Germinal matrix hemorrhage induces immune responses, brain injury, and motor impairment in neonatal rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Thrombocytopenia: is it a prognostic factor for development of post-hemorrhagic hydrocephalus in neonates?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  14. Review
  15. Article
  16. A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups.Frontiers in cellular neuroscience · 2020
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tim Lekic
Damon Klebe
Roy Poblete
Paul R Krafft
William B Rolland
Jiping Tang
John H ZhangDepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall Rm 219, Loma Linda, California, 92354, USA. johnzhang3910@yahoo.com.
Loma Linda University · US

Funding

Vascular Biology Core FacilityP01NS082184 · NINDS · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2014 to 2018
$6.1M
Mechanisms of Hyperbaric Oxygen Induced Brain ProtectionR01NS043338 · NINDS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ZHANG, JOHN H · 2004 to 2014
$3.0M
Mechanisms of EPO-Induced NeuroprotectionR01NS054685 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2007 to 2011
$1.8M
Harness Germinal Matrix HemorrhageR01NS078755 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2012 to 2016
$1.7M
Oxygen Therapy in Neonatal Hypoxia-IschemiaR01HD043120 · NICHD · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ZHANG, JOHN H. · 2003 to 2007
$1.6M
NICHD NIH HHS HD43120NICHD NIH HHS R01 HD043120NINDS NIH HHS NS078755NINDS NIH HHS NS43338NINDS NIH HHS NS54685NINDS NIH HHS P01 NS082184NINDS NIH HHS R01 NS043338NINDS NIH HHS R01 NS054685NINDS NIH HHS R01 NS078755
6 · The paper itself

Abstract

Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to study this condition, and many basic mechanisms, etiological factors, and outcome consequences, are becoming understood. NBH is an important clinical condition, of which treatment may potentially circumvent shunt complication, and improve functional recovery (cerebral palsy, and cognitive impairments). This review highlights key pathophysiological findings of the neonatal vascular-neural network in the context of molecular mechanisms targeting the posthemorrhagic hydrocephalus affecting this vulnerable infant population.

Indexed as

Infant, PrematureCerebral HemorrhageCerebrospinal FluidHumansInfant, NewbornNerve Net

Identifiers

PMID25620100
PMCPMC4495901
OpenAlexW2123666191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.