ArticleMolecular nutrition & food research2015
Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice.
Article in Molecular nutrition & food research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions.Frontiers in pharmacology · 2022Pooled it
- Pooled it
- Potential ofNutrients · 2020Pooled it
- Effects ofNutrients · 2022Trial
- Trial
- Effect ofNutrients · 2018Trial
- Network pharmacology refined with non-ubiquity and decoy-controlled molecular docking reveals insights intoFrontiers in bioinformatics · 2026Article
- HarnessingInternational journal of molecular sciences · 2025Review
- Biological Activities of Glucosinolate and Its Enzymatic Product inInternational journal of molecular sciences · 2025Article
- Oral Sulforaphane Intervention Protects Against Diabetic Cardiomyopathy in db/db Mice: Focus on Cardiac Lipotoxicity and Substrate Metabolism.Antioxidants (Basel, Switzerland) · 2025Article
- Effects of moringa (Moringa oleifera) silage on milk yield, milk composition and serum biochemical indexes of lactating Pabna cattle.Tropical animal health and production · 2025Article
- Review
- Phytochemistry and antifatigue activities ofNarra J · 2024Article
- Comparative Neuroprotective Effects ofTheScientificWorldJournal · 2024Article
- Promising Influences ofEndocrine, metabolic & immune disorders drug targets · 2024Review
- Dietary patterns and diabetic microvascular complications risk: a Mendelian randomization study of European ancestry.Frontiers in nutrition · 2024Article
- Efficacy of Hot Tea Infusion vs. Ethanolic Extract ofJournal of nutrition and metabolism · 2024Article
- Isothiocyanate-rich moringa seed extract reduces skin inflammation in mouse ear edema model.Phytomedicine plus : international journal of phytotherapy and phytopharmacology · 2023Article
- Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts ofOxidative medicine and cellular longevity · 2023Article
- Coffee intake and risk of diabetic nephropathy: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
scopeMoringa oleifera (moringa) is tropical plant traditionally used as an antidiabetic food. It produces structurally unique and chemically stable moringa isothiocyanates (MICs) that were evaluated for their therapeutic use in vivo. METHODS AND
resultsC57BL/6L mice fed very high fat diet (VHFD) supplemented with 5% moringa concentrate (MC, delivering 66 mg/kg/d of MICs) accumulated fat mass, had improved glucose tolerance and insulin signaling, and did not develop fatty liver disease compared to VHFD-fed mice. MC-fed group also had reduced plasma insulin, leptin, resistin, cholesterol, IL-1β, TNFα, and lower hepatic glucose-6-phosphatase (G6P) expression. In hepatoma cells, MC and MICs at low micromolar concentrations inhibited gluconeogenesis and G6P expression. MICs and MC effects on lipolysis in vitro and on thermogenic and lipolytic genes in adipose tissue in vivo argued these are not likely primary targets for the anti-obesity and anti-diabetic effects observed.
conclusionData suggest that MICs are the main anti-obesity and anti-diabetic bioactives of MC, and that they exert their effects by inhibiting rate-limiting steps in liver gluconeogenesis resulting in direct or indirect increase in insulin signaling and sensitivity. These conclusions suggest that MC may be an effective dietary food for the prevention and treatment of obesity and type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.