Evidence map›Paper›PMID 25619976›Full record

ArticleHistopathology2015

Handling and reporting of orchidectomy specimens with testicular cancer: areas of consensus and variation among 25 experts and 225 European pathologists.

Daniel M Berney, Ferran Algaba, Mahul Amin, Brett Delahunt, Eva Compérat, Jonathan I Epstein, Peter Humphrey, Mohammed Idrees, Antonio Lopez-Beltran, Cristina Magi-Galluzzi and 12 more

Open access · greenAbstract read
In one paragraph

Article in Histopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Testicular Germ-Cell Tumors with Spermatic Cord Involvement: A Retrospective International Multi-Institutional Experience.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  6. Review
  7. Pathological predictors of metastatic disease in testicular non-seminomatous germ cell tumors: which tumor-node-metastasis staging system?Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Article
  8. Article
  9. Prospective molecular and morphological assessment of testicular prepubertal-type teratomas in postpubertal men.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 20 institutions in 9 countries.

Daniel M BerneyBarts Cancer Institute, Queen Mary University of London, London, UK.
Ferran AlgabaFundacio Puigvert-University Autonomous, Barcelona, Spain.
Mahul AminDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Brett DelahuntDepartment of Pathology, Wellington School of Medicine and Health Sciences and University of Otago, Wellington, New Zealand.
Eva CompératHôpital La Pitié-Salpetrière, Paris, France.
Jonathan I EpsteinJohns Hopkins Hospital, Baltimore, MD, USA.
Peter HumphreyYale School of Medicine, Yale-New Haven Hospital, New Haven, CT, USA.
Mohammed IdreesDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine and Indiana Pathology Institute, Indianapolis, IN, USA.
Antonio Lopez-BeltranCordoba University Medical School, Cordoba, Spain.
Cristina Magi-GalluzziRobert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Gregor MikuzInstitute of Pathology, Medical University of Innsbruck, Innsbruck, Austria.
Rodolfo MontironiPolytechnic University of the Marche Region, Ancona, Italy.
Esther OlivaDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
John SrigleyDepartment Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Victor E ReuterDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Kiril TrpkovDepartment of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, AB, Canada.
Thomas M UlbrightDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine and Indiana Pathology Institute, Indianapolis, IN, USA.
Murali VarmaUniversity Hospital of Wales, Cardiff, UK.
Clare VerrillDepartment of Cellular Pathology, John Radcliffe Hospital, Oxford, UK.
Robert H YoungDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ming ZhouDepartment of Pathology, New York University Langone Medical Center, New York, NY, USA.
Lars EgevadDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Indiana University – Purdue University Indianapolis · USMassachusetts General Hospital · USCalgary Laboratory Services · CACedars-Sinai Medical Center · USCleveland Clinic · USCordoba University · USJohn Radcliffe Hospital · GBJohns Hopkins Hospital · USKarolinska Institutet · SEMarche Polytechnic University · ITMcMaster University · CAMemorial Sloan Kettering Cancer Center · USNYU Langone Health · USPitié-Salpêtrière Hospital · FRPuigvert Foundation · ESQueen Mary University of London · GBUniversität Innsbruck · ATUniversity Hospital of Wales · GBUniversity of Otago · NZYale New Haven Hospital · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

aimsThe handling and reporting of testicular tumours is difficult due to their rarity. METHODS AND

resultsA survey developed by the European Network of Uro-Pathology (ENUP) and sent to its members and experts to assess the evaluation of testicular germ cell tumours. Twenty-five experts and 225 ENUP members replied. Areas of disagreement included immaturity in teratomas, reported by 32% of experts but 68% of ENUP. Although the presence of rete testis invasion was reported widely, the distinction between pagetoid and stromal invasion was made by 96% of experts but only 63% of ENUP. Immunohistochemistry was used in more than 50% of cases by 68% of ENUP and 12% of experts. Staging revealed the greatest areas of disagreement. Invasion of the tunica vaginalis without vascular invasion was interpreted as T1 by 52% of experts and 67% of ENUP, but T2 by the remainder. Tumour invading the hilar adipose tissue adjacent to the epididymis without vascular invasion was interpreted as T1: 40% of experts, 43% of ENUP; T2: 36% of experts, 30% of ENUP; and T3: 24% of experts, 27% of ENUP.

conclusionsThere is remarkable consensus in many areas of testicular pathology. Significant areas of disagreement included staging and reporting of histological types, both of which have the potential to impact on therapy.

Indexed as

ConsensusEuropeExpert TestimonyHumansImmunohistochemistryMaleNeoplasm InvasivenessNeoplasms, Germ Cell and EmbryonalNeoplasm StagingObserver VariationOrchiectomySpecimen HandlingSurveys and QuestionnairesTesticular Neoplasmsclassificationconsensusgerm cell tumourrete testisstagingtestis

Identifiers

PMID25619976
PMCPMC5026308
OpenAlexW2125901167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.