ArticleUltrasound in medicine & biology2015
Non-invasive in vivo characterization of human carotid plaques with acoustic radiation force impulse ultrasound: comparison with histology after endarterectomy.
Article in Ultrasound in medicine & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 71 citations in OpenAlex.
- Experimental Evaluation of an Array Transducer for Ultrasound Thermal Strain Imaging: Phantom and In Vivo Studies.Ultrasound in medicine & biology · 2025Article
- Varying pixel resolution significantly improves deep learning-based carotid plaque histology segmentation.Scientific reports · 2025Article
- Polyvinyl Alcohol Phantoms With Heterogeneous Plaques: Estimation of Pulse Wave Velocity at the Stenotic Region Using Pulse Wave Imaging.Ultrasound in medicine & biology · 2024Article
- Unsupervised deep learning-based displacement estimation for vascular elasticity imaging applications.Physics in medicine and biology · 2023Article
- Comparing Focused-Tracked and Plane Wave-Tracked ARFI Log(VoA) In Silico and in Application to Human Carotid Atherosclerotic Plaque, Ex Vivo.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Pulse wave imaging of a stenotic artery model with plaque constituents of different stiffnesses: Experimental demonstration in phantoms and fluid-structure interaction simulation.Journal of biomechanics · 2023Article
- Feasibility of longitudinal monitoring of atherosclerosis with pulse wave imaging in a swine model.Physiological measurement · 2021Article
- Deep Convolutional Neural Networks for Displacement Estimation in ARFI Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Pulse Wave Imaging Coupled With Vector Flow Mapping: A Phantom, Simulation, and In Vivo Study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Computer-assisted ultrasound assessment of plaque characteristics in radiation-induced and non-radiation-induced carotid atherosclerosis.Quantitative imaging in medicine and surgery · 2021Article
- Wave Propagation in a Fractional Viscoelastic Tissue Model: Application to Transluminal Procedures.Sensors (Basel, Switzerland) · 2021Article
- Experimental Evidence of Generation and Reception by a Transluminal Axisymmetric Shear Wave Elastography Prototype.Diagnostics (Basel, Switzerland) · 2021Article
- Carotid Plaque Fibrous Cap Thickness Measurement by ARFI Variance of Acceleration: In Vivo Human Results.IEEE transactions on medical imaging · 2020Article
- Association between periodontal disease and vulnerable plaque morphology in patients undergoing carotid endarterectomy.International journal of cardiology. Heart & vasculature · 2020Article
- Extent and characteristics of carotid plaques and brain parenchymal loss in asymptomatic patients with no indication for revascularization.International journal of cardiology. Heart & vasculature · 2020Article
- Arterial wall mechanical inhomogeneity detection and atherosclerotic plaque characterization using high frame rate pulse wave imaging in carotid artery disease patients in vivo.Physics in medicine and biology · 2020Article
- The correlation between novel peripheral blood cell ratios and 90-day mortality in patients with acute ischemic stroke.PloS one · 2020Article
- Adaptive Pulse Wave Imaging: Automated Spatial Vessel Wall Inhomogeneity Detection in Phantoms and in-Vivo.IEEE transactions on medical imaging · 2020Article
- Comparison of Predictive Ability of Computed Tomography and Magnetic Resonance Imaging in Patients with Carotid Atherosclerosis Complicated with Stroke.Iranian journal of public health · 2019Article
- Delineation of Human Carotid Plaque Features In Vivo by Exploiting Displacement Variance.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Observational
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Ischemic stroke from thromboembolic sources is linked to carotid artery atherosclerotic disease with a trend toward medical management in asymptomatic patients. Extent of disease is currently diagnosed by non-invasive imaging techniques that measure luminal stenosis, but it has been suggested that a better biomarker for determining risk of future thromboembolic events is plaque morphology and composition. Specifically, plaques that are composed of mechanically soft lipid/necrotic regions covered by thin fibrous caps are the most vulnerable to rupture. An ultrasound technique that non-invasively interrogates the mechanical properties of soft tissue, called acoustic radiation force impulse (ARFI) imaging, has been developed as a new modality for atherosclerotic plaque characterization using phantoms and atherosclerotic pigs, but the technique has yet to be validated in vivo in humans. In this preliminary study, in vivo ARFI imaging is presented in a case study format for four patients undergoing clinically indicated carotid endarterectomy and compared with histology. In two type Va plaques, characterized by lipid/necrotic cores covered by fibrous caps, mean ARFI displacements in focal regions were high relative to the surrounding plaque material, suggesting soft features were covered by stiffer layers within the plaques. In two type Vb plaques, characterized by heavy calcification, mean ARFI peak displacements were low relative to the surrounding plaque and arterial wall, suggesting stiff tissue. This pilot study illustrates the feasibility and challenges of transcutaneous ARFI for characterizing the material and structural composition of carotid atherosclerotic plaques via mechanical properties, in humans, in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.