ArticleCurrent biology : CB2015
Olfactory neuromodulation of motion vision circuitry in Drosophila.
Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed.
- Odor tracking in flyingProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Odor tracking in flyingbioRxiv : the preprint server for biology · 2026Article
- Simultaneous recording of spikes and calcium signals in odor-evoked responses ofJournal of neurogenetics · 2025Article
- Extinction of Innate Floral Preferences in the Generalist Solitary Pollinator Eristalis tenax.Journal of chemical ecology · 2025Article
- Context-dependent effects of carbon dioxide on cross-modal integration during mosquito flight.Scientific reports · 2025Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Moving in an Uncertain World: Robust and Adaptive Control of Locomotion from Organisms to Machine Intelligence.Integrative and comparative biology · 2024Review
- Divergent visual ecology of Drosophila species drives object-tracking strategies matched to landscape sparsity.Current biology : CB · 2024Article
- Optokinetic response in D. melanogaster reveals the nature of common repellent odorants.Scientific reports · 2024Article
- Mosquitoes integrate visual and acoustic cues to mediate conspecific interactions in swarms.Current biology : CB · 2024Article
- Heterogeneity in the projections and excitability of tyraminergic/octopaminergic neurons that innervate theFrontiers in molecular neuroscience · 2024Article
- Neural mechanisms to incorporate visual counterevidence in self-movement estimation.Current biology : CB · 2023Article
- A comprehensive neuroanatomical survey of thebioRxiv : the preprint server for biology · 2023Article
- Neural mechanisms to incorporate visual counterevidence in self motion estimation.bioRxiv : the preprint server for biology · 2023Article
- Precise CRISPR-Cas9-mediated mutation of a membrane trafficking domain in theCurrent research in physiology · 2023Article
- Behavioral algorithms and neural mechanisms underlying odor-modulated locomotion in insects.The Journal of experimental biology · 2023Review
- Neural Circuits Underlying Behavioral Flexibility: Insights FromFrontiers in behavioral neuroscience · 2021Review
- Multisensory control of navigation in the fruit fly.Current opinion in neurobiology · 2020Review
- Serotonergic modulation of visual neurons in Drosophila melanogaster.PLoS genetics · 2020Article
- Neuromodulation of insect motion vision.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
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10 authors.
Funding
Abstract
It is well established that perception is largely multisensory; often served by modalities such as touch, vision, and hearing that detect stimuli emanating from a common point in space; and processed by brain tissue maps that are spatially aligned. However, the neural interactions among modalities that share no spatial stimulus domain yet are essential for robust perception within noisy environments remain uncharacterized. Drosophila melanogaster makes its living navigating food odor plumes. Odor acts to increase the strength of gaze-stabilizing optomotor reflexes to keep the animal aligned within an invisible plume, facilitating odor localization in free flight. Here, we investigate the cellular mechanism for cross-modal behavioral interactions. We characterize a wide-field motion-selective interneuron of the lobula plate that shares anatomical and physiological similarities with the "Hx" neuron identified in larger flies. Drosophila Hx exhibits cross-modal enhancement of visual responses by paired odor, and presynaptic inputs to the lobula plate are required for behavioral odor tracking but are not themselves the target of odor modulation, nor is the neighboring wide-field "HSE" neuron. Octopaminergic neurons mediating increased visual responses upon flight initiation also show odor-evoked calcium modulations and form connections with Hx dendrites. Finally, restoring synaptic vesicle trafficking within the octopaminergic neurons of animals carrying a null mutation for all aminergic signaling is sufficient to restore odor-tracking behavior. These results are the first to demonstrate cellular mechanisms underlying visual-olfactory integration required for odor localization in fruit flies, which may be representative of adaptive multisensory interactions across taxa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.