Evidence map›Paper›PMID 25619753›Full record

ArticleDiagnostic microbiology and infectious disease2015

Superantigens in Staphylococcus aureus isolated from prosthetic joint infection.

Choon K Kim, Melissa J Karau, Kerryl E Greenwood-Quaintance, Ashenafi Y Tilahun, Chella S David, Jayawant N Mandrekar, Robin Patel, Govindarajan Rajagopalan

Open access · greenAbstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Surveillance of osteoarticular infections caused byFrontiers in cellular and infection microbiology · 2022
    Article
  5. Genotypic and Phenotypic Characteristics ofOpen forum infectious diseases · 2020
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Choon K KimDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Division of Infectious Diseases, Veterans Health Service Medical Center, Seoul, Republic of Korea.
Melissa J KarauDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Kerryl E Greenwood-QuaintanceDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Ashenafi Y TilahunDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Chella S DavidDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Jayawant N MandrekarDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Robin PatelDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: patel.robin@mayo.edu.
Govindarajan RajagopalanDivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USWinnMed · USMayo Clinic in Florida · US

Funding

The Electricidal Effect, a Novel Anti-Biofilm StrategyR01AI091594 · NIAID · MAYO CLINIC ROCHESTER · PI Haluk Beyenal, Robin Patel · 2011 to 2026
$5.5M
Molecular Detection of Biofilms on Hip and Knee ImplantsR01AR056647 · NIAMS · MAYO CLINIC ROCHESTER · PI PATEL, ROBIN · 2009 to 2020
$4.5M
HLA class II transgenic mouse models for S. aureus infections and superantigensR01AI068741 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI RAJAGOPALAN, GOVINDARAJAN · 2007 to 2016
$3.1M
Novel Combination Therapy for Staphylococcus aureus PneumoniaR21AI101172 · NIAID · MAYO CLINIC ROCHESTER · PI RAJAGOPALAN, GOVINDARAJAN · 2012 to 2013
$425k
NIAID NIH HHS AI101172NIAID NIH HHS R01 AI068741NIAID NIH HHS R01 AI091594NIAID NIH HHS R01 AI91594NIAID NIH HHS R21 AI101172NIAMS NIH HHS R01 AR056647
6 · The paper itself

Abstract

Staphylococcus aureus is a common cause of prosthetic joint infection (PJI). The prevalence of superantigens (SAgs) among PJI-associated S. aureus is unknown. Eighty-four S. aureus isolates associated with PJI isolated between 1999 and 2006 were studied. SAg genes, sea, seb, sec, sed, see, seg, seh, sei, and tst, were assayed by PCR. Seventy-eight (92.9%) isolates carried at least 1 SAg gene studied, with 61 (72.6%) harboring more than 1. seg was most commonly (70.2%), and seh was least frequently (4.8%) detected. tst-positive isolates were associated with early infection and increased erythrocyte sedimentation rate at diagnosis (P=0.006 and P=0.021, respectively). seg and sei were associated with methicillin resistance (P=0.008 and P=0.002, respectively). A majority of PJI-associated isolates studied produced biologically active SAgs in both planktonic and biofilm growth modes. SAg genes are prevalent in S. aureus causing PJI.

Indexed as

AdultAgedAged, 80 and overAnimalsArthritisCell ProliferationCells, CulturedFemaleGenotypeHumansLeukocytes, MononuclearMaleMice, TransgenicMiddle AgedPolymerase Chain ReactionProsthesis-Related InfectionsSuperantigensProsthetic joint infectionS. aureusSuperantigen

Identifiers

PMID25619753
PMCPMC4336809
OpenAlexW2114646282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.