Evidence map›Paper›PMID 25619494›Full record

ArticleCancer medicine2015

Differences in IGF-axis protein expression and survival among multiethnic breast cancer patients.

Brenda Y Hernandez, Lynne R Wilkens, Loïc Le Marchand, David Horio, Clayton D Chong, Lenora W M Loo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Brenda Y HernandezUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, Hawaii.
Lynne R Wilkens
Loïc Le Marchand
David Horio
Clayton D Chong
Lenora W M Loo
University of Hawaiʻi at Mānoa · USCancer Center of Hawaii · USUniversity of Hawaii Cancer Center

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
Obesity and IGF-axis Activation in Native Hawaiian Women with Breast CancerR21CA176555 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI LOO, LENORA WM · 2014 to 2015
$365k
NCI NIH HHS 3P30CA071789-12S7NCI NIH HHS P30 CA071789NCI NIH HHS R21 CA176555PHS HHS HHSN261200900299P
6 · The paper itself

Abstract

There is limited knowledge about the biological basis of racial/ethnic disparities in breast cancer outcomes. Aberrations in IGF signaling induced by obesity and other factors may contribute to these disparities. This study examines the expression profiles of the insulin-like growth factor (IGF)-axis proteins and the association with breast cancer survival across a multiethnic population. We examined the expression profiles of the IGF1, IGF1R, IGFBP2 (IGF-binding proteins), and IGFBP3 proteins in breast tumor tissue and their relationships with all-cause and breast cancer-specific survival up to 17 years postdiagnosis in a multiethnic series of 358 patients in Hawaii, USA. Native Hawaiians, Caucasians, and Japanese were compared. Covariates included demographic and clinical factors and ER/PR/HER2 (estrogen receptor/progesterone receptor/human epidermal growth factor receptor-2) status. In Native Hawaiian patients, IGFBP2 and IGFBP3 expression were each independently associated with overall and breast cancer mortality (IGFB2: HR(mort) = 10.96, 95% CI: 2.18-55.19 and HR(mort) = 35.75, 95% CI: 3.64-350.95, respectively; IGFBP3: HR(mort) = 5.16, 95% CI: 1.27-20.94 and HR(mort) = 8.60, 95% CI: 1.84-40.15, respectively). IGF1R expression was also positively associated with all-cause mortality in Native Hawaiians. No association of IGF-axis protein expression and survival was observed in Japanese or Caucasian patients. The interaction of race/ethnicity and IGFBP3 expression on mortality risk was significant. IGF-axis proteins may have variable influence on breast cancer progression across different racial/ethnic groups. Expression of binding proteins and receptors in breast tumors may influence survival in breast cancer patients by inducing aberrations in IGF signaling and/or through IGF-independent mechanisms. Additional studies to evaluate the role of the IGF-axis in breast cancer are critical to improve targeted breast cancer treatment strategies.

Indexed as

AdultAgedBreast NeoplasmsEthnicityFemaleHawaiiHumansInsulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiddle AgedReceptor, IGF Type 1Receptors, SomatomedinIGF1 protein, humanIGF1R protein, humanIGFBP2 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IReceptor, IGF Type 1Receptors, SomatomedinBreast cancerIGF1IGF1RIGFBP2IGFBP3insulin-axis proteinmultiethnic

Identifiers

PMID25619494
PMCPMC4380961
OpenAlexW2015335019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.