ArticleIntensive care medicine2015
Comparison of different equations to assess glomerular filtration in critically ill patients.
Article in Intensive care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Augmented Renal Clearance in Critically Ill Patients: A Systematic Review.Clinical pharmacokinetics · 2018Pooled it
- Cefepime-induced neurotoxicity: a systematic review.Critical care (London, England) · 2017Pooled it
- Trial
- Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis.Intensive care medicine · 2016Trial
- Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial.Intensive care medicine · 2015Trial
- Toward the Future: A Race-Agnostic, Bayesian Approach to Defining Glomerular Filtration for Personalized Drug Dosing.Clinical pharmacology and therapeutics · 2026Review
- Brain-kidney crosstalk in subarachnoid hemorrhage patients.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Article
- The association of early glomerular filtration kinetics and urinary urea excretion with subsequent renal replacement therapy under a delayed strategy in severe acute kidney injury.Critical care (London, England) · 2026Article
- Deceased kidney donor cystatin C and subsequent recipient measured glomerular filtration rate at one year after transplantation.PloS one · 2026Article
- Comparing Cystatin C Estimated GFR With Creatinine Estimated GFR in Acute Kidney Injury Recovery.Kidney international reports · 2025Article
- Population pharmacokinetics of intravenous fosfomycin: dose optimization for critically ill patients with and without kidney replacement therapy.Antimicrobial agents and chemotherapy · 2025Observational
- Complementary role of transcriptomic endotyping and protein-based biomarkers for risk stratification in sepsis-associated acute kidney injury.Critical care (London, England) · 2025Article
- Creatinine clearance in critically ill adults: prospective comparison of prediction by intensive care unit physicians and machine learning models.Intensive care medicine · 2024Article
- Weaning from Kidney Replacement Therapy in the Critically Ill Patient with Acute Kidney Injury.Journal of clinical medicine · 2024Review
- Article
- Cystatin C as a GFR Estimation Marker in Acute and Chronic Illness: A Systematic Review.Kidney medicine · 2023Article
- Creatinine Clearance in Acute Brain Injury: A Comparison of Methods.Neurocritical care · 2023Observational
- Glomerular filtration rate in critically ill neonates and children: creatinine-based estimations versus iohexol-based measurements.Pediatric nephrology (Berlin, Germany) · 2023Article
- Onset timing and duration of augmented renal clearance in a mixed intensive care unit.Journal of intensive care · 2023Article
- Total and Unbound Pharmacokinetics of Cefiderocol in Critically Ill Patients.Pharmaceutics · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate equations for estimation of glomerular filtration rate (GFR) and measured urinary creatinine clearance, compared to measured GFR in critically ill patients.
methodsGFR was measured using inulin clearance. Multiple blood samples were collected per patient for determination of serum creatinine, cystatin C and inulin. GFR was estimated by the use of the following estimation equations (eGFR): four commonly used creatinine-based equations [Cockcroft-Gault, Modification of Diet in Renal Disease (both the short and long formula) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)], five cystatin C based estimation equations (Hoek, Larsson, Filler, Le Bricon, CKD-EPIcys) and one equation combining cystatin C and serum creatinine (CKD-EPIcr-cys). In addition we measured urinary creatinine clearance. Bias, precision and accuracy of all estimates were compared to those of the inulin clearance.
resultsData were collected from 83 patients, of whom 68 were considered evaluable. The median age was 58 years [interquartile range (IQR) 39-68]. The median inulin clearance was 80 mL/min/1.73 m(2) (IQR 31-114). Equations based on creatinine had much bias and poor precision and accuracy. Measured urinary creatinine clearances overestimated GFR. Equations based on cystatin C were free of bias, but also had limited precision and accuracy.
conclusionsIn this cohort of patients, estimates of GFR had low accuracy and precision. Cystatin C based formulas, especially CKD-EPIcr-cys, showed limited bias; however, the accuracy and precision of these estimates were still insufficient. Measured urinary creatinine clearance overestimates GFR, but may provide a cheap alternative, when this is taken into account.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.