Evidence map›Paper›PMID 25619480›Full record

ReviewReviews in endocrine & metabolic disorders2015

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity.

Ningwen Tai, F Susan Wong, Li Wen

Open access · greenAbstract readReview
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 1 synthesis or guideline pooled it, 252 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Recent advances in the positive role ofFrontiers in immunology · 2026
    Review
  5. Article
  6. Review
  7. Review
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  11. Review
  12. Review
  13. Article
  14. Mechanism ofMarine drugs · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Heliyon · 2024
    Article
  19. Diabetes and gut microbiome.Frontiers in microbiology · 2024
    Review
  20. Review

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ningwen TaiSection of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, USA.
F Susan Wong
Li Wen
Yale University · USCardiff University · GB

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Role of TLR9 in Beta Cell Function and DiabetesR01DK092882 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2012 to 2016
$1.8M
Dendritic cells in immuno-metabolic disorder in mouse and manR01DK100500 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2014 to 2017
$1.4M
Environment, innate immunity and type 1 diabetesR01DK088181 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2010 to 2013
$1.4M
INTESTINAL ADAPTATION AND APOPTOSISF32DK009882 · NIDDK · CHILDREN'S HOSPITAL MED CTR (CINCINNATI) · PI STERN, LAWRENCE E · 1998 to 1999
–
NCATS NIH HHS UL1 TR000142NCRR NIH HHS UL1 RR 024139NCRR NIH HHS UL1 RR024139NIDDK NIH HHS DK088181NIDDK NIH HHS DK09882NIDDK NIH HHS DK100500NIDDK NIH HHS F32 DK009882NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK088181NIDDK NIH HHS R01 DK092882NIDDK NIH HHS R01 DK100500
6 · The paper itself

Abstract

Diabetes is a group of metabolic disorders characterized by persistent hyperglycemia and has become a major public health concern. Autoimmune type 1 diabetes (T1D) and insulin resistant type 2 diabetes (T2D) are the two main types. A combination of genetic and environmental factors contributes to the development of these diseases. Gut microbiota have emerged recently as an essential player in the development of T1D, T2D and obesity. Altered gut microbiota have been strongly linked to disease in both rodent models and humans. Both classic 16S rRNA sequencing and shot-gun metagenomic pyrosequencing analysis have been successfully applied to explore the gut microbiota composition and functionality. This review focuses on the association between gut microbiota and diabetes and discusses the potential mechanisms by which gut microbiota regulate disease development in T1D, T2D and obesity.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Gastrointestinal TractHumansMicrobiotaObesity

Identifiers

PMID25619480
PMCPMC4348024
OpenAlexW2043161337

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.