Evidence map›Paper›PMID 25619313›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2015

Association between CYP1B1 gene polymorphisms and risk factors and susceptibility to laryngeal cancer.

Peng-Ju Yu, Wei-Guan Chen, Quan-Lin Feng, Wei Chen, Man-Jie Jiang, Ze-Qing Li

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Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and AtherosclerosisAsian Pacific journal of cancer prevention : APJCP · 2018
    Review
  4. The Clinical Signification of Claudin-11 Promoter Hypermethylation for Laryngeal Squamous Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  5. Article
  6. Article
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Peng-Ju YuDepartment of Otolaryngology, Jiangsu Province Academy of Traditional Chinese Medicine, Kunshan, Jiangsu, China (mainland).
Wei-Guan ChenOperation Room, Jiangsu Province Academy of Traditional Chinese Medicine, Kunshan, Jiangsu, China (mainland).
Quan-Lin FengDepartment of Tumor Surgical, Jiangsu Province Academy of Traditional Chinese Medicine, Kunshan, Jiangsu, China (mainland).
Wei ChenDepartment of Otolaryngology - Head and Neck Surgery, Jiangsu Province Academy of Traditional Chinese Medicine, Kunshan, Jiangsu, China (mainland).
Man-Jie JiangDepartment of Otolaryngology - Head and Neck Surgery, Jiangsu Province Academy of Traditional Chinese Medicine, Kunshan, Jiangsu, China (mainland).
Ze-Qing LiDepartment of Otolaryngology - Head and Neck Surgery, China Jiangsu Province Traditional Chinese Medicine Hospital, Nanjing, Jiangsu, China (mainland).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to investigate the association between polymorphism of the cytochrome P450 1B1 (CYP1B1) gene, a metabolic enzyme gene, and the susceptibility to laryngeal cancer among the Chinese Han population. MATERIAL/

methodsIn a case-control study, we investigated polymorphisms in the CYP1B1 gene (rs10012, rs1056827, and rs1056836) with a real-time quantitative polymerase chain reaction (PCR) assay (TaqMan). The study was conducted with 300 Chinese Han patients with laryngeal cancer and 300 healthy Chinese Han subjects in a control group. We also studied the interactions between genetic polymorphism and risk factors such as smoking and alcohol consumption in the pathogenesis of laryngeal cancer.

resultsThere were statistically significant differences in the distributions of the rs1056827 and rs1056836 genotypes between the 2 groups. Regarding rs1056827, carriers of the T allele had a significantly higher risk of laryngeal cancer than the G-allele carriers (OR=1.4339, 95% CI: 1.1268-1.8247; P=0.0034). The difference was still statistically significant after adjusting for factors such as age, sex, smoking, and drinking (adjusted OR=1.743, 95% CI: 1.124-3.743, P<0.001). However, regarding rs1056836, the G allele carriers had a significantly lower risk of laryngeal cancer than the C allele carriers (OR=0.5557, 95% CI: 0.3787-0.8154; P=0.0027). The difference was statistically significant even after adjusting for factors such as age, sex, smoking, and drinking (adjusted OR=0.5641, 95% CI: 0.3212-0.8121, P=0.001). Subjects who carry the C-T-C haplotype have a significantly increased incidence of laryngeal cancer. We also found that CYP1B1 rs1056827 polymorphism had synergistic effects with smoking or alcohol consumption regarding the risk of laryngeal cancer.

conclusionsCYP1B1 gene polymorphism is closely related to the onset of laryngeal cancer. There is a mutually synergistic effect between smoking, alcohol consumption, and CYP1B1 gene polymorphisms regarding laryngeal cancer.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticAgedAlcohol DrinkingAllelesCase-Control StudiesChinaCytochrome P-450 CYP1B1FemaleGenotypeHaplotypesHumansLaryngeal NeoplasmsMaleMiddle AgedMutationCYP1B1 protein, humanCytochrome P-450 CYP1B1

Identifiers

PMID25619313
PMCPMC4307736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.