Evidence map›Paper›PMID 25619230›Full record

ArticleNeuropathology : official journal of the Japanese Society of Neuropathology2015

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program.

Thomas G Beach, Charles H Adler, Lucia I Sue, Geidy Serrano, Holly A Shill, Douglas G Walker, LihFen Lue, Alex E Roher, Brittany N Dugger, Chera Maarouf and 28 more

Abstract read
In one paragraph

Article in Neuropathology : official journal of the Japanese Society of Neuropathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 353 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
353citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

353 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Article
  9. Brain-derived plasma p-tau217 shows enhanced dynamic range for Alzheimer's disease neuropathological change.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  10. Increased Binding of [Synapse (New York, N.Y.) · 2026
    Article
  11. Article
  12. Article
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  15. Integrative multi-omics identifiesPsychological medicine · 2026
    Article
  16. Article
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  18. Article
  19. Article
  20. Article

293 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Thomas G BeachBanner Sun Health Research Institute, Sun City, Arizona, USA.
Charles H AdlerMayo Clinic, Scottsdale, Arizona, USA.
Lucia I SueBanner Sun Health Research Institute, Sun City, Arizona, USA.
Geidy SerranoBanner Sun Health Research Institute, Sun City, Arizona, USA.
Holly A ShillBanner Sun Health Research Institute, Sun City, Arizona, USA.
Douglas G WalkerBanner Sun Health Research Institute, Sun City, Arizona, USA.
LihFen LueBanner Sun Health Research Institute, Sun City, Arizona, USA.
Alex E RoherBanner Sun Health Research Institute, Sun City, Arizona, USA.
Brittany N DuggerBanner Sun Health Research Institute, Sun City, Arizona, USA.
Chera MaaroufBanner Sun Health Research Institute, Sun City, Arizona, USA.
Alex C BirdsillBanner Sun Health Research Institute, Sun City, Arizona, USA.
Anthony IntorciaBanner Sun Health Research Institute, Sun City, Arizona, USA.
Megan Saxon-LabelleBanner Sun Health Research Institute, Sun City, Arizona, USA.
Joel PullenBanner Sun Health Research Institute, Sun City, Arizona, USA.
Alexander ScrogginsBanner Sun Health Research Institute, Sun City, Arizona, USA.
Jessica FilonBanner Sun Health Research Institute, Sun City, Arizona, USA.
Sarah ScottBanner Sun Health Research Institute, Sun City, Arizona, USA.
Brittany HoffmanBanner Sun Health Research Institute, Sun City, Arizona, USA.
Angelica GarciaBanner Sun Health Research Institute, Sun City, Arizona, USA.
John N CavinessMayo Clinic, Scottsdale, Arizona, USA.
Joseph G HentzMayo Clinic, Scottsdale, Arizona, USA.
Erika Driver-DunckleyMayo Clinic, Scottsdale, Arizona, USA.
Sandra A JacobsonBanner Sun Health Research Institute, Sun City, Arizona, USA.
Kathryn J DavisBanner Sun Health Research Institute, Sun City, Arizona, USA.
Christine M BeldenBanner Sun Health Research Institute, Sun City, Arizona, USA.
Kathy E LongBanner Sun Health Research Institute, Sun City, Arizona, USA.
Michael Malek-AhmadiBanner Sun Health Research Institute, Sun City, Arizona, USA.
Jessica J PowellBanner Sun Health Research Institute, Sun City, Arizona, USA.
Lisa D GaleBanner Sun Health Research Institute, Sun City, Arizona, USA.
Lisa R NicholsonBanner Sun Health Research Institute, Sun City, Arizona, USA.
Richard J CaselliMayo Clinic, Scottsdale, Arizona, USA.
Bryan K WoodruffMayo Clinic, Scottsdale, Arizona, USA.
Steven Z RapscakUniversity of Arizona, Tucson, Arizona, USA.
Geoffrey L AhernUniversity of Arizona, Tucson, Arizona, USA.
Jiong ShiBarrow Neurological Institute, Phoenix, Arizona, USA.
Anna D BurkeBanner Alzheimer Institute, Phoenix, Arizona, USA.
Eric M ReimanBanner Alzheimer Institute, Phoenix, Arizona, USA.
Marwan N SabbaghBanner Sun Health Research Institute, Sun City, Arizona, USA.

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
National Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8M
NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG19610NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain-only donations and currently has banked more than 1600 brains. More than 430 whole-body donations have been received since this service was commenced in 2005. The collective academic output of the BBDP is now described as the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Most BBDP subjects are enrolled as cognitively normal volunteers residing in the retirement communities of metropolitan Phoenix, Arizona. Specific recruitment efforts are also directed at subjects with Alzheimer's disease, Parkinson's disease and cancer. The median age at death is 82. Subjects receive standardized general medical, neurological, neuropsychological and movement disorders assessments during life and more than 90% receive full pathological examinations by medically licensed pathologists after death. The Program has been funded through a combination of internal, federal and state of Arizona grants as well as user fees and pharmaceutical industry collaborations. Subsets of the Program are utilized by the US National Institute on Aging Arizona Alzheimer's Disease Core Center and the US National Institute of Neurological Disorders and Stroke National Brain and Tissue Resource for Parkinson's Disease and Related Disorders. Substantial funding has also been received from the Michael J. Fox Foundation for Parkinson's Research. The Program has made rapid autopsy a priority, with a 3.0-hour median post-mortem interval for the entire collection. The median RNA Integrity Number (RIN) for frozen brain and body tissue is 8.9 and 7.4, respectively. More than 2500 tissue requests have been served and currently about 200 are served annually. These requests have been made by more than 400 investigators located in 32 US states and 15 countries. Tissue from the BBDP has contributed to more than 350 publications and more than 200 grant-funded projects.

Indexed as

Tissue and Organ ProcurementTissue BanksAged, 80 and overAgingArizonaAutopsyBiomarkersBrainFemaleHumansMaleNeurodegenerative DiseasesOrgan PreservationPostmortem ChangesTissue DonorsTissue SurvivalBiomarkersagingAlzheimer's diseaseautopsybiobankbiospecimenbrain bankcancerfreeze-thawParkinson's diseasepathologypost-mortem intervalRNA

Identifiers

PMID25619230
PMCPMC4593391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.