Evidence map›Paper›PMID 25618617›Full record

ArticleNeurobiology of aging2015

Whole genome sequences of 2 octogenarians with sustained cognitive abilities.

Dorothee Nickles, Lohith Madireddy, Nihar Patel, Noriko Isobe, Bruce L Miller, Sergio E Baranzini, Joel H Kramer, Jorge R Oksenberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dorothee NicklesDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Lohith MadireddyDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Nihar PatelMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Noriko IsobeDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Sergio E BaranziniDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Joel H KramerMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. Electronic address: JKramer@Memory.ucsf.edu.
Jorge R OksenbergDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA. Electronic address: jorge.oksenberg@ucsf.edu.

Funding

PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
The contribution of common and rare variants to autoimmunity in African AmericansR01NS076492 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OKSENBERG, JORGE R. · 2011 to 2014
$1.3M
NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289NIA NIH HHS R01AG032289NINDS NIH HHS R01 NS076492NINDS NIH HHS R01NS76492
6 · The paper itself

Abstract

Although numerous genetic variants affecting aging and mortality have been identified, for example, apolipoprotein E ε4, the genetic component influencing cognitive aging has not been fully defined yet. A better knowledge of the genetics of aging will prove helpful in understanding the underlying biological processes. Here, we describe the whole genome sequences of 2 female octogenarians. We provide the repertoire of genomic variants that the 2 octogenarians have in common. We also describe the overlap with the previously reported genomes of 2 supercentenarians—individuals aged ≥110 years. We assessed the genetic disease propensities of the octogenarians and non-aged control genomes and could not find support for the hypothesis that long-lived healthy individuals might exhibit greater genetic fitness than the general population. Furthermore, there is no evidence for an accumulation of previously described variants promoting longevity in the 2 octogenarians. These findings suggest that genetic fitness, as currently defined, is not the sole factor enabling an increased life span. We identified a number of healthy-cognitive-aging candidate genetic loci awaiting confirmation in larger studies.

Indexed as

GenomicsAged, 80 and overAgingApolipoprotein E4CognitionFemaleGenes, OverlappingGenetic Predisposition to DiseaseGenetic VariationGenome, HumanHumansLongevityPrecision MedicineApolipoprotein E4AgingAPOEε4CognitionGeneticsNext generation sequencingPersonalized medicine

Identifiers

PMID25618617
PMCPMC4346472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.