ArticleGenome biology and evolution2015
A Coxiella-like endosymbiont is a potential vitamin source for the Lone Star tick.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 1 of them a synthesis that pooled it.
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Who cites it
136 citing papers in PubMed, 1 synthesis or guideline pooled it, 272 citations in OpenAlex.
- The Prevalence ofFrontiers in veterinary science · 2021Pooled it
- Genomic Evolution of Francisella: Metabolic Innovation, Endosymbiotic Transitions to Ticks, and Biogeographic History.Genome biology and evolution · 2026Article
- Decoupling Abundance from Centrality: Sexual Dimorphism and Geographical Structuring in thePathogens (Basel, Switzerland) · 2026Article
- Feeding-state is associated with shifts in the Haemaphysalis bispinosa microbiome and its potential as a sentinel for circulating livestock pathogens.Veterinary research communications · 2026Article
- Stepwise assembly of virulence-associated traits in the intracellular pathogenbioRxiv : the preprint server for biology · 2026Article
- Environmental Low Temperatures Dynamically Reshape the Microbial Diversity and Community Structure of the Vector Tick Haemaphysalis longicornis.Archives of insect biochemistry and physiology · 2026Article
- Transcriptome of Coxiella-like endosymbionts in Haemaphysalis longicornis during blood feeding.The Journal of veterinary medical science · 2026Article
- Interaction between tick and host microbiotas: a four-step waltz.Parasites & vectors · 2026Review
- Rhipicephalus sanguineus s.l. ticks (Acari: Ixodidae) harbor non-divergent bacterial microbiomes in Arizona.Journal of medical entomology · 2026Article
- First evidence of naturally vertically transmitted Coxiella-like endosymbionts in Haemaphysalis bispinosa from dairy cattle in Indonesia.Scientific reports · 2026Article
- Francisella spp. as an overlooked cause of acute undifferentiated febrile illness in Colombia? Unexpected evidence from febrile patients negative for other common and neglected etiologies in Villeta municipality.Tropical medicine and health · 2026Article
- Sources and culture methods for the isolation and cultivation ofFrontiers in microbiology · 2026Review
- Article
- Molecular Detection and Prevalence ofPathogens (Basel, Switzerland) · 2025Article
- Sexual and regional differences in the microbiome and functional metagenome of the lone star tick, Amblyomma americanum.Animal microbiome · 2025Article
- Microbiome diversity in Haemaphysalis flava (life stage-host dependent) and Haemaphysalis longicornis ticks with zoonotic implications in Nantong, China.Acta parasitologica · 2025Article
- Evolutionary Convergence of Nutritional Symbionts in Ticks.Environmental microbiology reports · 2025Article
- Molecular prevalence of Coxiella like endosymbionts and the first record of Coxiella burnetii in hard ticks from Southern Thailand.Scientific reports · 2025Article
- The Tick Microbiome: The "Other Bacterial Players" in Tick Biocontrol.Microorganisms · 2024Review
- The epidemiological and infectious characteristics of novel types of Coxiella burnetii co-infected with Coxiella-like microorganisms from Xuyi County, Jiangsu province, China.BMC infectious diseases · 2024Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Amblyomma americanum (Lone star tick) is an important disease vector in the United States. It transmits several human pathogens, including the agents of human monocytic ehrlichiosis, tularemia, and southern tick-associated rash illness. Blood-feeding insects (Class Insecta) depend on bacterial endosymbionts to provide vitamins and cofactors that are scarce in blood. It is unclear how this deficiency is compensated in ticks (Class Arachnida) that feed exclusively on mammalian blood. A bacterium related to Coxiella burnetii, the agent of human Q fever, has been observed previously within cells of A. americanum. Eliminating this bacterium (CLEAA, Coxiella-like endosymbiont of A. americanum) with antibiotics reduced tick fecundity, indicating that it is an essential endosymbiont. In an effort to determine its role within this symbiosis, we sequenced the CLEAA genome. While highly reduced (656,901 bp) compared with C. burnetii (1,995,281 bp), the CLEAA genome encodes most major vitamin and cofactor biosynthesis pathways, implicating CLEAA as a vitamin provisioning endosymbiont. In contrast, CLEAA lacks any recognizable virulence genes, indicating that it is not a pathogen despite its presence in tick salivary glands. As both C. burnetii and numerous "Coxiella-like bacteria" have been reported from several species of ticks, we determined the evolutionary relationship between the two bacteria. Phylogeny estimation revealed that CLEAA is a close relative of C. burnetii, but was not derived from it. Our results are important for strategies geared toward controlling A. americanum and the pathogens it vectors, and also contribute novel information regarding the metabolic interdependencies of ticks and their nutrient-provisioning endosymbionts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.