ArticleSocial cognitive and affective neuroscience2015
Neural indicators of emotion regulation via acceptance vs reappraisal in remitted major depressive disorder.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Comparing reappraisal and acceptance strategies to understand the neural architecture of emotion regulation: a meta-analytic approach.Frontiers in psychology · 2023Pooled it
- Mindfulness in the focus of the neurosciences - The contribution of neuroimaging to the understanding of mindfulness.Frontiers in behavioral neuroscience · 2022Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Acceptance versus reappraisal: Behavioral, autonomic, and neural effects.Cognitive, affective & behavioral neuroscience · 2019Trial
- Effects of five-minute internet-based cognitive behavioral therapy and simplified emotion-focused mindfulness on depressive symptoms: a randomized controlled trial.BMC psychiatry · 2017Trial
- Sadness regulation in daily life in remitted depression: Regulatory repertoire composition and affect-dependent effectiveness.Journal of affective disorders · 2026Article
- Common and distinct neurofunctional signatures of dynamic naturalistic emotion regulation strategies.Nature communications · 2026Article
- Successful mood repair in the laboratory predicts successful mood repair in daily life for typical but not for depression-prone young adults.Emotion (Washington, D.C.) · 2025Article
- Neural correlates of pain acceptance and the role of the cerebellum: Functional connectivity and anatomical differences in individuals with headaches versus matched controls.European journal of pain (London, England) · 2025Article
- Neural Functioning in Late-Life Depression: An Activation Likelihood Estimation Meta-Analysis.Geriatrics (Basel, Switzerland) · 2024Review
- Frontal alpha asymmetry during emotion regulation in adults with lifetime major depression.Cognitive, affective & behavioral neuroscience · 2024Article
- The antidepressant effect of cognitive reappraisal training on individuals cognitively vulnerable to depression: Could cognitive bias be modified through the prefrontal-amygdala circuits?Frontiers in human neuroscience · 2022Article
- Hypoactivation of autonomtic nervous system-related orbitofrontal and motor cortex during acute stress in women with premenstrual syndrome.Neurobiology of stress · 2021Article
- Modulation of amygdala reactivity following rapidly acting interventions for major depression.Human brain mapping · 2020Article
- Acceptance as an Emotion Regulation Strategy in Experimental Psychological Research: What We Know and How We Can Improve That Knowledge.Frontiers in psychology · 2020Article
- Article
- Nonacceptance of negative emotions in women with borderline personality disorder: association with neuroactivity of the dorsal striatumJournal of psychiatry & neuroscience : JPN · 2019Article
- Mindfulness-related differences in neural response to own infant negative versus positive emotion contexts.Developmental cognitive neuroscience · 2018Article
- Nicotine and networks: Potential for enhancement of mood and cognition in late-life depression.Neuroscience and biobehavioral reviews · 2018Review
- Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder.Social cognitive and affective neuroscience · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Mood disorders are characterized by impaired emotion regulation abilities, reflected in alterations in frontolimbic brain functioning during regulation. However, little is known about differences in brain function when comparing regulatory strategies. Reappraisal and emotional acceptance are effective in downregulating negative affect, and are components of effective depression psychotherapies. Investigating neural mechanisms of reappraisal vs emotional acceptance in remitted major depressive disorder (rMDD) may yield novel mechanistic insights into depression risk and prevention. Thirty-seven individuals (18 rMDD, 19 controls) were assessed during a functional magnetic resonance imaging task requiring reappraisal, emotional acceptance or no explicit regulation while viewing sad images. Lower negative affect was reported following reappraisal than acceptance, and was lower following acceptance than no explicit regulation. In controls, the acceptance > reappraisal contrast revealed greater activation in left insular cortex and right prefrontal gyrus, and less activation in several other prefrontal regions. Compared with controls, the rMDD group had greater paracingulate and right midfrontal gyrus (BA 8) activation during reappraisal relative to acceptance. Compared with reappraisal, acceptance is associated with activation in regions linked to somatic and emotion awareness, although this activation is associated with less reduction in negative affect. Additionally, a history of MDD moderated these effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.