ArticleDevelopmental biology2015
Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Epigenetic regulation of kidney development.Nature reviews. Nephrology · 2026Review
- Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations.Nature biomedical engineering · 2026Article
- Epigenetic regulation of nephrogenesis: from Waddington's landscape to adult disease.American journal of physiology. Renal physiology · 2026Review
- Derivation of Granulosa-Like Cells from Human Endometrial iPSCs for Autologous Estradiol Production.Tissue engineering and regenerative medicine · 2025Article
- Morphogenesis-coupled DNA repair - in mammalian embryogenesis, morphogenesis and DNA double strand break (DSB) repair are carried out simultaneously to ensure normal development.Journal of radiation research · 2024Article
- Multiple roles for Pax2 in the embryonic mouse eye.Developmental biology · 2021Article
- Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney.Journal of the American Society of Nephrology : JASN · 2020Article
- Regeneration after acute kidney injury requires PTIP-mediated epigenetic modifications.JCI insight · 2020Article
- Cellular and Molecular Mechanisms of Kidney Development: From the Embryo to the Kidney Organoid.Frontiers in cell and developmental biology · 2020Review
- MicroRNA-204-3p modulates epithelial-mesenchymal transition by targeting paired box gene 2 in human melanoma A-375 cells.Translational cancer research · 2019Article
- MAPK/ERK Signaling in Regulation of Renal Differentiation.International journal of molecular sciences · 2019Review
- Screening of genes involved in epithelial-mesenchymal transition and differential expression of complement-related genes induced by PAX2 in renal tubules.Nephrology (Carlton, Vic.) · 2019Article
- HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.Cancer cell · 2018Article
- Are Pax proteins potential therapeutic targets in kidney disease and cancer?Kidney international · 2018Review
- Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.Developmental cell · 2017Article
- Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain.ACS chemical biology · 2017Article
- Selective In Vitro Propagation of Nephron Progenitors Derived from Embryos and Pluripotent Stem Cells.Cell reports · 2016Article
- Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.Development (Cambridge, England) · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Activation of the Pax2 gene marks the intermediate mesoderm shortly after gastrulation, as the mesoderm becomes compartmentalized into paraxial, intermediate, and lateral plate. Using an EGFP knock-in allele of Pax2 to identify and sort cells of the intermediate mesodermal lineage, we compared gene expression patterns in EGFP positive cells that were heterozygous or homozygous null for Pax2. Thus, we identified critical regulators of intermediate mesoderm and kidney development whose expression depended on Pax2 function. In cell culture models, Pax2 is thought to recruit epigenetic modifying complex to imprint activating histone methylation marks through interactions with the adaptor protein PTIP. In kidney organ culture, conditional PTIP deletion showed that many Pax2 target genes, which were activated early in renal progenitor cells, remained on once activated, whereas Pax2 target genes expressed later in kidney development were unable to be fully activated without PTIP. In Pax2 mutants, we also identified a set of genes whose expression was up-regulated in EGFP positive cells and whose expression was consistent with a cell fate transformation to paraxial mesoderm and its derivatives. These data provide evidence that Pax2 specifies the intermediate mesoderm and renal epithelial cells through epigenetic mechanisms and in part by repressing paraxial mesodermal fate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.