Evidence map›Paper›PMID 25617600›Full record

ReviewSeminars in cell & developmental biology2015

Emerging trends in the pathophysiology of lymphatic contractile function.

Sanjukta Chakraborty, Michael J Davis, Mariappan Muthuchamy

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 71 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Dynamic multispectral NIR/SWIR forJournal of biomedical optics · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Lymphatic Pathophysiology.Microcirculation (New York, N.Y. : 1994) · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. KAmerican journal of physiology. Cell physiology · 2022
    Review
  17. Review
  18. Dermal Lymphatic Capillaries Do Not Obey Murray's Law.Frontiers in cardiovascular medicine · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sanjukta ChakrabortyDepartment of Medical Physiology, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A&M Health Science Center College of Medicine, United States.
Michael J DavisDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, United States. Electronic address: davismj@health.missouri.edu.
Mariappan MuthuchamyDepartment of Medical Physiology, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A&M Health Science Center College of Medicine, United States. Electronic address: marim@email.tamu.edu.
Texas A&M Health Science Center · US

Funding

Lymphatic pacemaking and pumping in lymphedema: function, dysfunction, and rescueR01HL122578 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2023
$4.1M
Conduction and coordination of electrical signals within the lymphatic vascular wallR01HL125608 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2018
$1.6M
Mechanisms of lymphatic valve and pump dysfunction in lymphedemaR01HL120867 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2014 to 2017
$1.5M
Role of mesenteric lymphatics and dietary endotoxin in metabolic syndromeR01DK099221 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MUTHUCHAMY, MARIAPPAN, ZAWIEJA, DAVID CARL · 2013 to 2015
$976k
NHLBI NIH HHS R01 HL120867NHLBI NIH HHS R01 HL122578NHLBI NIH HHS R01 HL125608NIDDK NIH HHS R01 DK099221NIDDK NIH HHS R01 DK99221
6 · The paper itself

Abstract

Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of people worldwide. Due to its critical role in the process of inflammation, a dysfunctional lymphatic system also compromises the immune response, further exacerbating a number of inflammation related diseases. Despite the critical physiological functions accomplished by the transport of lymph, a complete understanding of the contractile machinery of the lymphatic system lags far behind that of the blood vasculature. However, there has been a surge of recent research focusing on different mechanisms that underlie both physiological and pathophysiological aspects of lymphatic contractile function. This review summarizes those emerging paradigms that shed some novel insights into the contractile physiology of the lymphatics in normal as well as different disease states. In addition, this review emphasizes the recent progress made in our understanding of various contractile parameters and regulatory elements that contribute to the normal functioning of the lymphatics.

Indexed as

AgingAnimalsAtherosclerosisHumansInflammationLymphLymphatic VesselsMetabolic SyndromeObesityInflammationLymphatic contractionLymphatic muscleLymphatic valveLymph flowNitric oxide

Identifiers

PMID25617600
PMCPMC4397138
OpenAlexW2093754469

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.