ArticleDevelopment (Cambridge, England)2015
Cavefish eye loss in response to an early block in retinal differentiation progression.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Parallel sensory compensation following independent subterranean colonization by groundwater salamanders (Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution.Antioxidants (Basel, Switzerland) · 2024Review
- Trait Loss in Evolution: What Cavefish Have Taught Us about Mechanisms Underlying Eye Regression.Integrative and comparative biology · 2023Review
- Discovery of putative long non-coding RNAs expressed in the eyes of Astyanax mexicanus (Actinopterygii: Characidae).Scientific reports · 2023Article
- Cavefishes in Chronobiological Research: A Narrative Review.Clocks & sleep · 2023Review
- Eye morphogenesis in the blind Mexican cavefish.Biology open · 2021Article
- Variation in Pleiotropic Hub Gene Expression Is Associated with Interspecific Differences in Head Shape and Eye Size in Drosophila.Molecular biology and evolution · 2021Article
- Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair.PLoS genetics · 2021Article
- Comparative development and ocular histology between epigean and subterranean salamanders (PeerJ · 2021Article
- Eye Degeneration and Loss of otx5b Expression in the Cavefish Sinocyclocheilus tileihornes.Journal of molecular evolution · 2019Article
- Extra-Visual Systems in the Spatial Reorientation of Cavefish.Scientific reports · 2018Article
- Evolution shapes the responsiveness of the D-box enhancer element to light and reactive oxygen species in vertebrates.Scientific reports · 2018Article
- Mutations in blind cavefish target the light-regulated circadian clock gene, period 2.Scientific reports · 2018Article
- Article
- Sequential organogenesis sets two parallel sensory lines in medaka.Development (Cambridge, England) · 2017Article
- Cavefish and the basis for eye loss.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- An Overview of Monthly Rhythms and Clocks.Frontiers in neurology · 2017Review
- Article
- Distinct developmental genetic mechanisms underlie convergently evolved tooth gain in sticklebacks.Development (Cambridge, England) · 2015Article
- Article
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Authors and funding
5 authors.
Funding
Abstract
The troglomorphic phenotype shared by diverse cave-dwelling animals is regarded as a classical example of convergent evolution. One unresolved question is whether the characteristic eye loss in diverse cave species is based on interference with the same genetic program. Phreatichthys andruzzii, a Somalian cavefish, has evolved under constant conditions in complete darkness and shows severe troglomorphic characteristics, such as complete loss of eyes, pigments and scales. During early embryonic development, a complete eye is formed but is subsequently lost. In Astyanax mexicanus, another blind cavefish, eye loss has been attributed to interference during eye field patterning. To address whether similar pathways have been targeted by evolution independently, we investigated the retinal development of P. andruzzii, studying the expression of marker genes involved in eye patterning, morphogenesis, differentiation and maintenance. In contrast to Astyanax, patterning of the eye field and evagination of the optic vesicles proceeds without obvious deviation. However, the subsequent differentiation of retinal cell types is arrested during generation of the first-born cell type, retinal ganglion cells, which also fail to project correctly to the optic tectum. Eye degeneration in both species is driven by progressive apoptosis. However, it is retinal apoptosis in Phreatichthys that progresses in a wave-like manner and eliminates progenitor cells that fail to differentiate, in contrast to Astyanax, where lens apoptosis appears to serve as a driving force. Thus, evolution has targeted late retinal differentiation events, indicating that there are several ways to discontinue the development and maintenance of an eye.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.