ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2016
Depression and Frailty in Late Life: Evidence for a Common Vulnerability.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- The Frail Depressed Patient: A Narrative Review on Treatment Challenges.Clinical interventions in aging · 2022Pooled it
- Depression and frailty in later life: a systematic review.Clinical interventions in aging · 2015Pooled it
- Integrating Depression Care Management into Medicare Home Health Reduces Risk of 30- and 60-Day Hospitalization: The Depression Care for Patients at Home Cluster-Randomized Trial.Journal of the American Geriatrics Society · 2016Trial
- A High Geriatric Depression Scale Score on Admission to Hospital Predicts a Worse Clinical Frailty Scale Score After Discharge.Geriatrics & gerontology international · 2026Article
- Commentary on "A High Geriatric Depression Scale Score on Admission to Hospital Predicts a Worse Clinical Frailty Scale Score After Discharge".Geriatrics & gerontology international · 2026Article
- Relationship among frailty, nutrition, depression and quality of life in the older population.BMC geriatrics · 2026Article
- Integrated approaches to geriatric mental disorders: pathophysiology, interventions, and precision medicine horizons.Frontiers in psychiatry · 2026Review
- High-Accuracy Indoor Positioning and Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults.Sensors (Basel, Switzerland) · 2025Article
- Poorer performance on physical frailty-related parameters is associated with depression among older rural Indians.Scientific reports · 2025Article
- A serial mediation model of physical exercise and loneliness: the role of frailty and depression.BMC geriatrics · 2025Article
- The association between multimorbidity patterns and physical frailty among middle-aged and older community-dwelling adults: the mediating role of depressive symptoms.Frontiers in public health · 2025Article
- Social support and frailty progression in community-dwelling older adults.Frontiers in public health · 2024Article
- The 'discontinuity hypothesis' of depression in later life-clinical and research implications.Age and ageing · 2023Review
- Order of Onset of Physical Frailty and Cognitive Impairment and Risk of Repeated Falls in Community-Dwelling Older Adults.Journal of the American Medical Directors Association · 2023Observational
- Frailty transition and depression among community-dwelling older adults: the Korean Longitudinal Study of Aging (2006-2020).BMC geriatrics · 2023Article
- Data-driven health deficit assessment improves a frailty index's prediction of current cognitive status and future conversion to dementia: results from ADNI.GeroScience · 2023Article
- Case Report and Literature Review of an Atypical Polymyalgia Rheumatica and Its Management.International medical case reports journal · 2023Article
- Empowering frail older adults: multicomponent elastic-band exercises and BCAA supplementation unleash physical health and preserve haematological biomarkers.Frontiers in sports and active living · 2023Article
- The critical role of physical frailty and function on depressive symptoms among community-dwelling older adults in China: A cross-sectional study.Frontiers in psychiatry · 2023Article
- Mediating effects of depression on sleep disturbance and frailty in older adult type 2 diabetes patients in the community.Frontiers in public health · 2023Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe study purpose is to estimate the correlation between depression and competing models of frailty, and to determine to what degree the comorbidity of these syndromes is determined by shared symptomology.
methodsData come from the 2010 Health and Retirement Study. Analysis was limited to community-dwelling participants 65 and older (N = 3,453). Depressive symptoms were indexed by the 8-item Centers for Epidemiologic Studies Depression (CESD) scale. Frailty was indexed by 3 alternative conceptual models: (a) biological syndrome, (b) frailty index, and (c) functional domains. Confirmatory factor analysis (CFA) was used to estimate the correlation between depression and each model of frailty.
resultsEach of the 3 frailty latent factors was significantly correlated with depression: biological syndrome (ρ = .68, p < .01), functional domains (ρ = .70, p < .01), and frailty index (ρ = .61, p < .01). Substantial correlation remained when accounting for shared symptoms between depression and the biological syndrome (ρ = .45) and frailty index (ρ = .56) models. DISCUSSION: Results indicate that the correlation of frailty and depression in late life is substantial. The association between the two constructs cannot be fully explained by symptom overlap, suggesting that psychological vulnerability may be an important component of frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.