ArticleMolecular systems biology2015
From intracellular signaling to population oscillations: bridging size- and time-scales in collective behavior.
Article in Molecular systems biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Many Cells Make Light Work: Self-Generated Gradients OrganizeCold Spring Harbor perspectives in biology · 2026Review
- From microscope to model: rotating signaling dynamics and cluster size in Dictyostelium discoideum aggregates.BMC molecular and cell biology · 2026Article
- Benchmarking tools for deciphering cellular crosstalk in spatially-resolved transcriptomics.Genome biology · 2026Article
- Early cAMP signaling orchestrates single-cell synchronicity throughout Dictyostelium development.Communications biology · 2026Article
- Discreteness, Computation, and Rules of Life for Self-Organization Dynamics Beyond Equilibrium.Newton ((New York, N.Y.) · 2026Article
- Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function.Cell · 2025Review
- Systematic assessment of microenvironment-dependent transcriptional patterns and intercellular communication.Genome biology · 2025Article
- Cell-to-cell signaling in cell populations with large cell size variability.Biophysical journal · 2025Article
- Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming.Developmental cell · 2024Article
- The diversification of methods for studying cell-cell interactions and communication.Nature reviews. Genetics · 2024Review
- Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis.Results and problems in cell differentiation · 2024Review
- Article
- Rate thresholds in cell signaling have functional and phenotypic consequences in non-linear time-dependent environments.Frontiers in cell and developmental biology · 2023Review
- Reproducible and sensitive micro-tissue RNA sequencing from formalin-fixed paraffin-embedded tissues for spatial gene expression analysis.Scientific reports · 2022Article
- Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum.Scientific reports · 2022Article
- The macroscopic limit to synchronization of cellular clocks in single cells of Neurospora crassa.Scientific reports · 2022Article
- Towards a physical understanding of developmental patterning.Nature reviews. Genetics · 2021Review
- Arnold tongues in oscillator systems with nonuniform spatial driving.Physical review. E · 2021Article
- Article
- Spatial gradient sensing and chemotaxis via excitability in Dictyostelium discoideum.Physical review. E · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Collective behavior in cellular populations is coordinated by biochemical signaling networks within individual cells. Connecting the dynamics of these intracellular networks to the population phenomena they control poses a considerable challenge because of network complexity and our limited knowledge of kinetic parameters. However, from physical systems, we know that behavioral changes in the individual constituents of a collectively behaving system occur in a limited number of well-defined classes, and these can be described using simple models. Here, we apply such an approach to the emergence of collective oscillations in cellular populations of the social amoeba Dictyostelium discoideum. Through direct tests of our model with quantitative in vivo measurements of single-cell and population signaling dynamics, we show how a simple model can effectively describe a complex molecular signaling network at multiple size and temporal scales. The model predicts novel noise-driven single-cell and population-level signaling phenomena that we then experimentally observe. Our results suggest that like physical systems, collective behavior in biology may be universal and described using simple mathematical models.
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