SynthesisWorld journal of surgical oncology2015
Meta-analysis of defunctioning stoma in low anterior resection with total mesorectal excision for rectal cancer: evidence based on thirteen studies.
Synthesis in World journal of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Which site is better for prophylactic ileostomy after laparoscopic rectal cancer surgery? By the specimen extraction site or new site: A systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Virtual ileostomy in elective colorectal surgery: a systematic review of the literature.Techniques in coloproctology · 2020Pooled it
- Quality of life following ostomy reversal with purse-string vs linear skin closure: a systematic review.International journal of colorectal disease · 2019Pooled it
- Early Closure of Defunctioning Loop Ileostomy: Is It Beneficial for the Patient? A Meta-analysis.World journal of surgery · 2018Pooled it
- Efficacy of transanal tube placement after anterior resection for rectal cancer: a systematic review and meta-analysis.World journal of surgical oncology · 2016Pooled it
- Trial
- Early versus late reversal of diverting loop ileostomy in rectal cancer surgery: a multicentre randomized controlled trial.Scientific reports · 2023Trial
- Modified Albert-Lembert coloanal anastomosis with diverting ileostomy versus Turnbull-Cutait pull-through delayed coloanal anastomosis after intersphincteric resection for low rectal cancer: a single-center retrospective comparative study.World journal of surgical oncology · 2026Article
- Prevention and management of anastomotic leakage after colorectal resection: evolving trends among Italian surgeons. A SICCR survey.Updates in surgery · 2026Article
- Comparison of short-term outcomes among hand-sewn, stapled, and two-stage Turnbull-Cutait pull-through anastomoses in TaTME for low rectal cancer.Techniques in coloproctology · 2026Article
- A single-center retrospective study of prophylactic loop ileostomies and transverse end colostomies after laparoscopic radical resection for rectal cancer: a comparison of safety and functional outcomes.International journal of colorectal disease · 2026Observational
- Short-term outcomes of low anterior resection with and without ileostomy for low, mid and upper rectal cancers.Updates in surgery · 2025Article
- Machine learning prediction model of prolonged delay to loop ileostomy closure after rectal cancer surgery: a retrospective study.World journal of surgical oncology · 2025Article
- Article
- The impact of Low-Anterior Resection Syndrome (LARS) on the Quality of Life in Rectal Cancer Survivors: a Narrative Review.Maedica · 2025Review
- Increased risk of postoperative complications after delayed stoma reversal: a multicenter retrospective cohort study on patients undergoing anterior resection for rectal cancer.International journal of colorectal disease · 2025Article
- Current approach to loop ileostomy closure: a nationwide survey on behalf of the Italian Society of ColoRectal Surgery (SICCR).Updates in surgery · 2025Article
- Predictors of complications after prophylactic ileostomy reversal for rectal cancer: A retrospective study.World journal of gastrointestinal surgery · 2024Article
- Prophylactic defunctioning stomas improve clinical outcomes of anastomotic leak following rectal cancer resections: An analysis of the US Rectal Cancer Consortium.International journal of colorectal disease · 2024Article
- Short-term results in a population based study indicate advantage for minimally invasive rectal cancer surgery versus open.BMC surgery · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have shown that a protective stoma can reduce morbidity in low anterior resection for rectal cancer; however, the necessity of it is still controversially discussed.
methodsWe performed this meta-analysis to provide a comprehensive evaluation of the role of defunctioning stoma in low anterior resection for rectal cancer on the rates of anastomotic leakage and reoperation related to leakage with or without defunctioning stoma by calculating the pooled risk ratio.
resultsStudies and relevant literature published between 2004 and 2014 regarding the construction of a protective stoma after low anterior resection were searched though PubMed and EMBASE databases. Finally, a total of 13 studies including 8,002 patients were included in this meta-analysis. The results indicated that protective stomas significantly reduced the rate of postoperative anastomotic leakage and reoperation after low anterior rectal resection. The pooled risk ratios were 0.47 (95% CI: 0.33-0.68, P <0.0001) and 0.36 (95% CI: 028-0.46, P <0.00001), respectively.
conclusionsThe findings from this present meta-analysis suggest that a defunctioning stoma could effectively reduce the clinical consequences of anastomotic leakage and reoperation, it is recommended in patients undergoing low rectal anterior resection for rectal cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.