ArticleJournal of assisted reproduction and genetics2015
Morphokinetic parameters of early embryo development via time lapse monitoring and their effect on embryo selection and ICSI outcomes: a prospective cohort study.
Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Time-lapse systems for embryo incubation and assessment in assisted reproduction.The Cochrane database of systematic reviews · 2019Pooled it
- Time-lapse systems for embryo incubation and assessment in assisted reproduction.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Can Comprehensive Chromosome Screening Technology Improve IVF/ICSI Outcomes? A Meta-Analysis.PloS one · 2015Pooled it
- Association between early embryo morphokinetics plus transcript levels of sperm apoptotic genes and clinical outcomes in IMSI and ICSI cycles of male factor patients.Journal of assisted reproduction and genetics · 2020Trial
- A generalized AI system for human embryo selection covering the entire IVF cycle via multi-modal contrastive learning.Patterns (New York, N.Y.) · 2024Article
- The impact of oocyte central granularity on ICSI practice: developmental competence of dysmorphic and morphologically normal companion oocytes.Journal of assisted reproduction and genetics · 2023Article
- Time-Lapse Embryo culture: A better understanding of embryo development and clinical application.JBRA assisted reproduction · 2022Review
- The impact of endometriosis on embryo morphokinetics: embryos from endometriosis patients exhibit delayed cell cycle milestones and decreased blastulation rates.Journal of assisted reproduction and genetics · 2022Article
- Early-cleavage versus blastocyst stage embryo transfer: a prospective comparative studyJournal of the Turkish German Gynecological Association · 2021Article
- Change in the Strategy of Embryo Selection with Time-Lapse System Implementation-Impact on Clinical Pregnancy Rates.Journal of clinical medicine · 2021Article
- Comparison of pregnancy outcomes using a time-lapse monitoring system for embryo incubation versus a conventional incubator in in vitro fertilization: An age-stratification analysis.Clinical and experimental reproductive medicine · 2021Article
- Good practice recommendations for the use of time-lapse technologyHuman reproduction open · 2020Article
- Does polycystic ovary syndrome affect morphokinetics or abnormalities in early embryonic development?European journal of obstetrics & gynecology and reproductive biology: X · 2019Article
- Revealing the secret life of pre-implantation embryos by time-lapse monitoring: A review.International journal of reproductive biomedicine · 2017Review
- Do morphokinetic data sets inform pregnancy potential?Journal of assisted reproduction and genetics · 2016Article
- The clinical use of time-lapse in human-assisted reproduction.Therapeutic advances in reproductive healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the outcomes of embryos selected via time lapse monitoring (TLM) versus those selected with conventional methods of selection in subfertile women undergoing ICSI.
methodsThe study population (239 women) was classified into two groups, based on the monitoring method used: Group 1 (TLM) and Group 2 (conventional monitoring). Groups were compared according to the clinical and ICSI cycle characteristics and reproductive outcomes, while transfers were performed at day 2 or 3. Subgroup analyses were performed, in women of both groups according to age and clinical parameters, and in embryos of Group 1 based on their cellular events.
resultsThere was a statistically significant difference between the two study groups with regard to the outcome parameters, favoring Group 1 and especially in women >40 years of age. No differences were found in subgroup analyses in participants of both groups, regarding the stimulation protocol used, number of the oocytes retrieved and type of subfertility, while in Group 1 the percentages of "in range" cellular events were higher in certain divisions in ages 35-40, non-smokers, and the GnRH-agonist group, and in embryos that resulted in pregnancy.
conclusionMorphokinetic parameters of early embryo development via TLM are related to the characteristics of subfertile patients and associated with ICSI outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.