ReviewCurrent psychiatry reports2015
Anxiety and substance use disorders: co-occurrence and clinical issues.
Review in Current psychiatry reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Oral and Long-acting Injectable Aripiprazole in Severe Mental Illness and Substance Use Disorder Comorbidity: An Updated Systematic Review.Current neuropharmacology · 2025Pooled it
- Unhealthy behaviors associated with mental health disorders: a systematic comparative review of diet quality, sedentary behavior, and cannabis and tobacco use.Frontiers in public health · 2023Pooled it
- Cannabis Use and Prospective Long-Term Association with Anxiety: A Systematic Review and Meta-Analysis of Longitudinal Studies: Usage du cannabis et association prospective à long terme avec l'anxiété: une revue systématique et une méta-analyse d'études longitudinales.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Pooled it
- The Global Prevalence of Anxiety Among Medical Students: A Meta-Analysis.International journal of environmental research and public health · 2019Pooled it
- Longitudinal study of impact of medication for opioid use disorder on Hamilton Depression Rating Scale.Journal of affective disorders · 2022Trial
- Robust effects of food deprivation as a relapse trigger: comparison to other stressors, and investigation of predictive individual traits in male and female rats.Psychopharmacology · 2026Article
- Mental Health and Coping in Women With ADHD During the Pandemic.Journal of attention disorders · 2026Article
- A Behavioral Economic Characterization of the Impact of the COVID-19 Quarantine on Reinforcer Diversity, Behavior, and Health.Perspectives on behavior science · 2026Review
- An exploratory study of anxiety symptoms and associated factors among Kenyan youth recruited from colleges and communities in urban and peri-urban areas in the Nairobi Metropolitan.BMC psychiatry · 2026Article
- Combinations of mental disorders and their association with mortality in the UK Biobank.BMC psychiatry · 2026Article
- Synaptogyrin-3 plays a critical role in addiction-related dopamine dysfunction and behavioral maladaptations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Differential associations of mental health, mild traumatic brain injury and substance use between male and female university students.PloS one · 2026Article
- Anxiety and depression in emerging adults: The STAND program as a model of scalable screening and intervention.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- A shared ensemble in the prelimbic cortex links impulsivity and anxiety-like behavior.bioRxiv : the preprint server for biology · 2025Article
- Blocking IL-17A inhibits methamphetamine-induced hyperlocomotion and conditioned place preference and prevents methamphetamine abstinence-induced depression-like behaviors in mice.Neuropharmacology · 2025Article
- Evaluating health-related quality of life and health resource utilization among Gabapentinoid users with substance use disorder in the US: Trends, co-prescriptions, and cost analysis.Exploratory research in clinical and social pharmacy · 2025Article
- The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models.Microorganisms · 2025Article
- Case Report: Substance fixation in autism spectrum disorder with resultant anorexia nervosa.Frontiers in psychiatry · 2025Article
- The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework.Brain sciences · 2024Review
- Late-stage borreliosis and substance abuse.Heliyon · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The co-occurrence of substance use disorders (SUDs) and anxiety disorders has been now well established. This association is frequent and can be explained by three models: the shared vulnerability factors model, the self-medication model, and the substance-induced model. General population epidemiological studies provide strong evidence of the frequency of the association for the most used substances: tobacco, alcohol, cannabis, and to a lesser extent sedatives, opiates, and cocaine. For substances that are less commonly used in the general population, the frequency of the co-occurrence can more precisely be studied in clinical samples. We provide the most recent literature results on the association of SUDs and anxiety, and evidence for one explicative model or the other when available. For substances with sedative properties (alcohol, benzodiazepines, cannabis, opioids), both evidence for a self-medication and for a toxic effect exist. For substances with psychostimulant properties (tobacco, cocaine, and amphetamines), the literature favors the toxic hypothesis to explain the association with anxiety disorders. We give practical steps for the recognition of these dual diagnoses and present therapeutic issues, although the strategies are rarely evidence based.
Indexed as
Identifiers
25617040What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.