ArticleRespiratory research2015
Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β.
Article in Respiratory research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 81 citations in OpenAlex.
- Improved diet quality is associated with decreased concentrations of inflammatory markers in adults with uncontrolled asthma.The American journal of clinical nutrition · 2021Trial
- Differential DAMP release was observed in the sputum of COPD, asthma and asthma-COPD overlap (ACO) patients.Scientific reports · 2019Trial
- Potential Protective Role of Galectin-3 in Airway Dilatation in Obstructive Airway Diseases.Clinical and translational allergy · 2025Article
- Sputum quality affects assessment of airway microbiology in childhood asthma.Respiratory research · 2025Article
- Targeting Frequent Efferocytosis in Tumor Microenvironment is a New Direction for Cancer Treatment.Small science · 2025Review
- Review
- The role of immunoglobulin E in non-atopic disorders.Frontiers in immunology · 2025Review
- Efferocytosis in Homeostasis.Advances in experimental medicine and biology · 2025Review
- Species-level, metagenomic and proteomic analysis of microbe-immune interactions in severe asthma.Allergy · 2024Article
- Review
- The Role of Galectins in Asthma Pathophysiology: A Comprehensive Review.Current issues in molecular biology · 2024Review
- Article
- Efferocytosis and Respiratory Disease.International journal of molecular sciences · 2023Review
- Severe Asthmatic Responses: The Impact of TSLP.International journal of molecular sciences · 2023Review
- Neutrophil phenotypes in bronchial airways differentiate single from dual responding allergic asthmatics.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Article
- Biological Treatments and Target Therapies for Pediatric Respiratory Medicine: Not Only Asthma.Frontiers in pediatrics · 2022Article
- TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma.Frontiers in immunology · 2022Article
- Airway IL-1β associates with IL-5 production following dust mite allergen inhalation in humans.Respiratory research · 2021Article
- What's the deal with efferocytosis and asthma?Trends in immunology · 2021Review
- Leukotriene BBiomedicines · 2021Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGalectin-3 (gal-3), a member of the β-galactoside-binding animal lectins, is involved in the recruitment, activation and removal of neutrophils. Neutrophilic asthma is characterized by a persistent elevation of airway neutrophils and impaired efferocytosis. We hypothesized that sputum gal-3 would be reduced in neutrophilic asthma and the expression of gal-3 would be associated with other markers of neutrophilic inflammation.
methodsAdults with asthma (n = 80) underwent a sputum induction following clinical assessment and blood collection. Sputum was dispersed for a differential cell count and ELISA assessment of gal-3, gal-3 binding protein (BP), interleukin (IL)-1β, IL-1 receptor antagonist (RA), IL-8 and IL-6. Gal-3 and gal-3BP immunoreactivity were assessed in mixed sputum cells.
resultsSputum gal-3 (median, (q1,q3)) was significantly reduced in neutrophilic asthma (183 ng/mL (91,287)) compared with eosinophilic (293 ng/mL (188,471), p = 0.021) and paucigranulocytic asthma (399 ng/mL (213,514), p = 0.004). The gal-3/gal-3BP ratio and IL-1RA/IL-1β ratio were significantly reduced, while gal-3BP and IL-1β were significantly elevated in neutrophilic asthma compared with eosinophilic and paucigranulocytic asthma.
conclusionPatients with neutrophilic asthma have impairment in anti-inflammatory ratio of gal-3/gal-3BP and IL-1RA/IL-1β which provides a further framework for exploration into pathologic mechanisms of asthma phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.