ArticleApplied and environmental microbiology2015
In vivo selection to identify bacterial strains with enhanced ecological performance in synbiotic applications.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05668468 (Can Feeding a Bifido Bacteria That Readily Digests Lactose and Galactooligosacharides Improve Lactose Digestion and Tolerance Through Alteration of the Microbiome?), which is not on this map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Feeding a Bifido Bacteria That Readily Digests Lactose and Galactooligosacharides Improve Lactose Digestion and Tolerance Through Alteration of the Microbiome?
Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Trial
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- Relationship Between Diet Quality, Intestinal Permeability, and Gut Microbiota Features in Individuals with Obesity.Nutrients · 2026Article
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- Recent advances in the application of microbiota transplantation in chickens.Journal of animal science and biotechnology · 2025Review
- Generation of novel prebiotic oligosaccharide pools from fiber drives biological insight in bacterial glycan metabolism.Applied and environmental microbiology · 2025Article
- Nutritional Strategies in Major Depression Disorder: From Ketogenic Diet to Modulation of the Microbiota-Gut-Brain Axis.Molecular neurobiology · 2025Review
- Two-week supplementation ofGut microbes reports · 2025Article
- Harnessing Prebiotics to Improve Type 2 Diabetes Outcomes.Nutrients · 2024Review
- MicroencapsulatedAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- A comprehensive review of synbiotics: an emerging paradigm in health promotion and disease management.World journal of microbiology & biotechnology · 2024Review
- Complete genome sequence of the probioticMicrobiology resource announcements · 2023Article
- The Effect of Maternal Probiotic or Synbiotic Supplementation on Sow and Offspring Gastrointestinal Microbiota, Health, and Performance.Animals : an open access journal from MDPI · 2023Review
- The Future of Synbiotics: Rational Formulation and Design.Frontiers in microbiology · 2022Review
- Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease.Frontiers in cellular and infection microbiology · 2022Review
- Asthma and obesity: endotoxin another insult to add to injury?Clinical science (London, England : 1979) · 2021Review
- Human gut-derived B. longum subsp. longum strains protect against aging in a D-galactose-induced aging mouse model.Microbiome · 2021Article
- Quantitative Detection ofMicroorganisms · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One strategy for enhancing the establishment of probiotic bacteria in the human intestinal tract is via the parallel administration of a prebiotic, which is referred to as a synbiotic. Here we present a novel method that allows a rational selection of putative probiotic strains to be used in synbiotic applications: in vivo selection (IVS). This method consists of isolating candidate probiotic strains from fecal samples following enrichment with the respective prebiotic. To test the potential of IVS, we isolated bifidobacteria from human subjects who consumed increasing doses of galactooligosaccharides (GOS) for 9 weeks. A retrospective analysis of the fecal microbiota of one subject revealed an 8-fold enrichment in Bifidobacterium adolescentis strain IVS-1 during GOS administration. The functionality of GOS to support the establishment of IVS-1 in the gastrointestinal tract was then evaluated in rats administered the bacterial strain alone, the prebiotic alone, or the synbiotic combination. Strain-specific quantitative real-time PCR showed that the addition of GOS increased B. adolescentis IVS-1 abundance in the distal intestine by nearly 2 logs compared to rats receiving only the probiotic. Illumina 16S rRNA sequencing not only confirmed the increased establishment of IVS-1 in the intestine but also revealed that the strain was able to outcompete the resident Bifidobacterium population when provided with GOS. In conclusion, this study demonstrated that IVS can be used to successfully formulate a synergistic synbiotic that can substantially enhance the establishment and competitiveness of a putative probiotic strain in the gastrointestinal tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.