ArticleCardiovascular toxicology2016
Sulfide Intoxication-Induced Circulatory Failure is Mediated by a Depression in Cardiac Contractility.
Article in Cardiovascular toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Respiratory failure and central nervous system injury caused by mixed gas poisoning after inhaling naphtha vapor: three case reports.Frontiers in medicine · 2025Article
- GYY4137-Derived Hydrogen Sulfide Donates Electrons to the Mitochondrial Electron Transport Chain via Sulfide: Quinone Oxidoreductase in Endothelial Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Prolonged Cardiogenic Shock Due to Hydrogen Sulfide Intoxication Requiring Long-Term Venoarterial Extracorporeal Membrane Support.JACC. Case reports · 2022Article
- A Sulfonyl Azide-Based Sulfide Scavenger Rescues Mice from Lethal Hydrogen Sulfide Intoxication.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- An Updated Insight Into Molecular Mechanism of Hydrogen Sulfide in Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury Under Diabetes.Frontiers in pharmacology · 2021Review
- Antidotal Effects of the Phenothiazine Chromophore Methylene Blue Following Cyanide Intoxication.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Oxidative Stress Effects of Soluble Sulfide on Human Hepatocyte Cell Line LO2.International journal of environmental research and public health · 2019Article
- Methylene Blue Administration During and After Life-Threatening Intoxication by Hydrogen Sulfide: Efficacy Studies in Adult Sheep and Mechanisms of Action.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- On the Efficacy of Cardio-Pulmonary Resuscitation and Epinephrine Following Cyanide- and HCardiovascular toxicology · 2018Article
- Methylene Blue Counteracts HCardiovascular toxicology · 2018Article
- Total Flavones ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Circulatory Failure During Noninhaled Forms of Cyanide Intoxication.Shock (Augusta, Ga.) · 2017Article
- H2S concentrations in the heart after acute H2S administration: methodological and physiological considerations.American journal of physiology. Heart and circulatory physiology · 2016Article
- Is exogenous hydrogen sulfide a relevant tool to address physiological questions on hydrogen sulfide?Respiratory physiology & neurobiology · 2016Review
- Methylene blue counteracts H2S toxicity-induced cardiac depression by restoring L-type Ca channel activity.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations.Annals of the New York Academy of Sciences · 2016Review
- H2S induced coma and cardiogenic shock in the rat: Effects of phenothiazinium chromophores.Clinical toxicology (Philadelphia, Pa.) · 2015Article
- Cardiogenic shock induced reduction in cellular O2 delivery as a hallmark of acute H2S intoxication.Clinical toxicology (Philadelphia, Pa.) · 2015Article
- Immediate and Long-Term Outcome of Acute H2S Intoxication Induced Coma in Unanesthetized Rats: Effects of Methylene Blue.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hydrogen sulfide (H2S) intoxication produces a rapid cardio-circulatory failure leading to cardiac arrest. In non-lethal forms of sulfide exposure, the presence of a circulatory shock is associated with long-term neurological sequelae. Our aim was to clarify the mechanisms of H2S-induced circulatory failure. In anesthetized, paralyzed, and mechanically ventilated rats, cardiac output, arterial pressure and ventricular pressures were determined while NaHS was infused to increase arterial concentration of soluble H2S (CgH2S) from undetectable to levels leading to circulatory failure. Compared to control/saline infusion, blood pressure started to decrease significantly along with a modest drop in peripheral vascular resistance (-19 ± 5%, P < 0.01), when CgH2S reached about 1 μM. As CgH2S exceeded 2-3 μM, parameters of ventricular contractility diminished with no further reduction in peripheral resistance. Whenever H2S exposure was maintained at a higher level (CgH2S over 7 μM), a severe depression of cardiac contractility was observed, leading to asystole within minutes, but with no evidence of peripheral vasoplegia. The immediate and long-term neurological effects of specifically counteracting sulfide-induced cardiac contractility depression following H2S exposure remain to be investigated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.