ArticlePharmacology, biochemistry, and behavior2015
Bupropion-varenicline interactions and nicotine self-administration behavior in rats.
Article in Pharmacology, biochemistry, and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Targeting GPR3 as a novel approach for nicotine cessation therapeutic development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Bupropion decreases plasma levels of asymmetric dimethylarginine and ameliorates renal injury by modulation of Ddah1, Oatp4c1, Oct2, and Mate1 in rats with adenine-induced chronic renal injury.Frontiers in pharmacology · 2025Article
- Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options.Pharmacology, biochemistry, and behavior · 2024Review
- Methoxsalen Inhibits the Acquisition of Nicotine Self-Administration: Attenuation by Cotinine Replacement in Male Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- The involvement of mesolimbic dopamine system in cotinine self-administration in rats.Behavioural brain research · 2022Article
- Cannabinoid receptor GPR55 activation blocks nicotine use disorder by regulation of AMPAR phosphorylation.Psychopharmacology · 2021Article
- Neuroimmune Mechanisms as Novel Treatment Targets for Substance Use Disorders and Associated Comorbidities.Frontiers in neuroscience · 2021Review
- Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats.Journal of psychopharmacology (Oxford, England) · 2020Article
- Dextromethorphan and bupropion reduces high level remifentanil self-administration in rats.Pharmacology, biochemistry, and behavior · 2020Article
- Assessment of individual differences in response to acute bupropion or varenicline treatment using a long-access nicotine self-administration model and behavioral economics in female rats.Behavioural brain research · 2020Article
- Identification ofeLife · 2020Article
- The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice.The Journal of pharmacology and experimental therapeutics · 2020Article
- Acute and chronic interactive treatments of serotonin 5HTPharmacology, biochemistry, and behavior · 2019Article
- Individual differences in responding to bupropion or varenicline in a preclinical model of nicotine self-administration vary according to individual demand for nicotine.Neuropharmacology · 2019Article
- Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine DPharmacology, biochemistry, and behavior · 2019Article
- Mutually augmenting interactions of dextromethorphan and sazetidine-A for reducing nicotine self-administration in rats.Pharmacology, biochemistry, and behavior · 2018Article
- Neuropeptide systems and new treatments for nicotine addiction.Psychopharmacology · 2017Review
- Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats.Psychopharmacology · 2016Article
- Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline.Behavioural brain research · 2016Article
- Dextromethorphan interactions with histaminergic and serotonergic treatments to reduce nicotine self-administration in rats.Pharmacology, biochemistry, and behavior · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Varenicline and bupropion each have been shown to significantly improve cessation of tobacco addiction in humans. They act through different mechanisms and the question about the potential added efficacy with their combined used has arisen. Preclinical animal models of nicotine addiction can help with the evaluation of this combined approach and what dose combinations of varenicline and bupropion may be useful for enhancing tobacco cessation. In this study, we investigated the interacting dose-effect functions of varenicline and bupropion in a rat model of nicotine self-administration. Young adult female Sprague-Dawley rats were allowed to self-administer nicotine in 1-h sessions under an FR1 reinforcement schedule. Varenicline (0.3, 1. 3 mg/kg) and bupropion (8.33, 25, 75 mg/kg) were administered alone or together 15 min before each session. The vehicle saline was the control. Higher doses of each drug alone reduced nicotine self-administration compared to control with reductions of 62% and 75% with 3 mg/kg varenicline and 75 mg/kg bupropion respectively. Lower dose varenicline which does not by itself reduce nicotine self-administration, significantly augmented bupropion effects. The 0.3 mg/kg varenicline dose combined with the 25 and 75 mg/kg bupropion doses caused greater reductions of nicotine self-administration than either dose of bupropion given alone. However, higher dose varenicline did not have this effect. Lower dose bupropion did not augment varenicline effects. Only the high bupropion dose significantly enhanced the varenicline effect. Likewise, combining 1 mg/kg varenicline with 75 mg/kg bupropion reduced self-administration to a greater extent than either dose alone. These results demonstrate that combination therapy with varenicline and bupropion may be more beneficial than monotherapy with either drug alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.