ArticleMedical science monitor : international medical journal of experimental and clinical research2015
Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 104 citations in OpenAlex.
- Growth differentiation factor-15 as a potential biomarker in subclinical inflammation in familial mediterranean fever.Clinical rheumatology · 2026Article
- The cally index as an indicator of inflammatory burden across clinical phases of familial mediterranean fever.Clinical rheumatology · 2026Article
- The Association Between Platelet Indices and Osteoarthritis: A Systematic Review and Meta-analysis.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2026Article
- Evaluation of Hematological Parameters as Markers for Subclinical Inflammation in Adults with Familial Mediterranean Fever.Middle East journal of digestive diseases · 2024Article
- Pan-Immune-Inflammation Value Could Be a New Marker to Predict Amyloidosis and Disease Severity in Familial Mediterranean Fever.Diagnostics (Basel, Switzerland) · 2024Article
- Limited value of platelet-related markers in diagnosing periprosthetic joint infection.BMC musculoskeletal disorders · 2024Article
- Relationship between sacroiliitis and inflammatory markers in familial Mediterranean fever.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Neutrophil-to-Lymphocyte Ratio, Neutrophil-to-Monocyte Ratio, Platelet-to-Lymphocyte Ratio, and Systemic Immune-Inflammation Index in Psoriasis Patients: Response to Treatment with Biological Drugs.Journal of clinical medicine · 2023Article
- Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever.Irish journal of medical science · 2023Article
- Importance of hematological markers in familial Mediterranean fever in terms of disease severity and amyloidosis.Rheumatology international · 2023Article
- Association of Macrophage Migration Inhibitory Factor Gene -173 G/C Polymorphism (rs755622) with Familial Mediterranean Fever in Children.Journal of pediatric genetics · 2022Article
- The effectiveness of anti-interleukin-1 therapy on subclinical inflammation parameters during the attack-free period in familial Mediterranean fever patients: A case-control study.Turkish journal of medical sciences · 2022Article
- Evaluation of the controlling nutritional status score and prognostic nutritional index in patients with familial Mediterranean fever.European journal of rheumatology · 2022Article
- Article
- Familial Mediterranean fever and atherosclerosis in childhood and adolescence.Rheumatology international · 2020Review
- Arterial stiffness in Familial Mediterranean Fever: correlations with disease-related parameters and colchicine treatment.Clinical rheumatology · 2019Article
- The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases.Annals of laboratory medicine · 2019Review
- Observational
- Evaluation of hematological parameters in children with FMF.Clinical rheumatology · 2019Article
- New inflammatory markers in early rheumatoid arthritis.Zeitschrift fur Rheumatologie · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this study we investigated the potential of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell width distribution (RDW) as new inflammatory markers to identify chronic inflammations during symptom-free periods in children diagnosed with Familial Mediterranean Fever (FMF). MATERIAL/
methodsThe study included 153 children diagnosed with FMF based on the Tel-Hashomer Criteria, and 90 healthy volunteers. Hospital records were obtained to collect NLR, PLR, MPV, RDW, and FMF scores and the FMF mutation analyses of the patients enrolled in the study. Data on proteinuria were also collected and defined as a protein/creatinine ratio>0.2.
resultsNLR, PLR, MPV, and RDW were significantly higher in symptom-free FMF patients than in the control group. C-reactive protein values also weakly correlated with NLR, PLR, MPV, and RDW, but the correlation was not statistically significant. NLR had the strongest correlation with CRP. The NLR cut-off point to indicate subclinical inflammation in symptom-free FMF patients was calculated to be 1.65.
conclusionsNLR, PLR, MPV, and RDW are potential subclinical inflammation markers in patients with FMF. NLR, PLR, MPV, and RDW values are higher in patients with FMF during symptom-free periods. NLR was found to be the most reliable marker for subclinical inflammation when compared to PLR, MPV, and RDW. We also found that these markers are not significantly higher in proteinuric patients when compared with levels in non-proteinuric patients.
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