Evidence map›Paper›PMID 25615945›Full record

ArticleJournal of biotechnology2015

Advanced targeted nanomedicine.

Mohan C Pereira, Mohan C M Arachchige, Yana K Reshetnyak, Oleg A Andreev

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. The Promise of Nanotechnology in Personalized Medicine.Journal of personalized medicine · 2022
    Review
  6. Review
  7. Review
  8. Article
  9. Kinetics of pHLIP peptide insertion into and exit from a membrane.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  10. Review
  11. Review
  12. Article
  13. Personalized Nanomedicine: A Revolution at the Nanoscale.Journal of personalized medicine · 2017
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mohan C Pereira
Mohan C M ArachchigeDepartment of Physics, University of Rhode Island, 2 Lippit Rd., Kingston, RI 028881, USA.
Yana K ReshetnyakDepartment of Physics, University of Rhode Island, 2 Lippit Rd., Kingston, RI 028881, USA.
Oleg A AndreevDepartment of Physics, University of Rhode Island, 2 Lippit Rd., Kingston, RI 028881, USA. Electronic address: andreev@my.uri.edu.
University of Rhode Island · US

Funding

TM INTERACTIONS IN MEMBRANE PROTEIN FOLDING AND FUNCTIONR01GM073857 · NIGMS · YALE UNIVERSITY · PI ANDREEV, OLEG A, ENGELMAN, DONALD M. · 2006 to 2023
$8.4M
pHLIP Nanotechnology Platform for Cancer Imaging and TherapyR01CA133890 · NCI · UNIVERSITY OF RHODE ISLAND · PI ANDREEV, OLEG A, ENGELMAN, DONALD M. · 2008 to 2012
$3.8M
Mapping pH at the surface of individual cellR21CA174413 · NCI · UNIVERSITY OF RHODE ISLAND · PI ANDREEV, OLEG A, RESHETNYAK, YANA K · 2012 to 2013
$415k
NCI NIH HHS CA133890NCI NIH HHS CA174413NCI NIH HHS R01 CA133890NCI NIH HHS R21 CA174413NIGMS NIH HHS GM073857NIGMS NIH HHS R01 GM073857
6 · The paper itself

Abstract

Targeted drug delivery has been the major topic in drug formulation and delivery. As nanomedicine emerges to create nano scale therapeutics and diagnostics, it is still essential to embed targeting capability to these novel systems to make them useful. Here we discuss various targeting approaches for delivery of therapeutic and diagnostic nano materials in view of search for more universal methods to target diseased tissues. Many diseases are accompanied with hypoxia and acidosis. Coating nanoparticles with pH Low Insertion Peptides (pHLIPs) increases efficiency of targeting acidic diseased tissues. It has been showing promising results to create future nanotheranostics for cancer and other diseases which are dominating in the present world.

Indexed as

AnimalsCell-Penetrating PeptidesDrug Delivery SystemsHumansHydrogen-Ion ConcentrationNanoparticlesNeoplasmsTheranostic NanomedicineCell-Penetrating PeptidesActive targetingEnvironmental targetingNanomedicinePassive targetingpHLIPTissue acidity

Identifiers

PMID25615945
PMCPMC4685670
OpenAlexW2147141789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.