ReviewEuropean journal of immunology2015
Thymus medulla fosters generation of natural Treg cells, invariant γδ T cells, and invariant NKT cells: what we learn from intrathymic migration.
Review in European journal of immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 41 citations in OpenAlex.
- From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology.Immunological reviews · 2026Review
- Translational potential of γδ T cells in hematologic diseases: from immunobiology to therapeutic innovation.Frontiers in immunology · 2026Review
- Insm1: orchestrating cellular mimicry in the thymus medulla.Cellular & molecular immunology · 2024Article
- Review
- The medulla controls effector primed γδT-cell development in the adult mouse thymus.European journal of immunology · 2023Article
- Embryonic keratin19Nature communications · 2023Article
- Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration.Science immunology · 2022Article
- Key Factors for Thymic Function and Development.Frontiers in immunology · 2022Review
- Difference in the distribution of tumor-infiltrating CD8+ T cells and FOXP3+ T cells between micronodular thymoma with lymphoid stroma and micronodular thymic carcinoma with lymphoid stroma.Pathology international · 2021Article
- Arming Immune Cells for Battle: A Brief Journey through the Advancements of T and NK Cell Immunotherapy.Cancers · 2021Review
- Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.Frontiers in immunology · 2021Article
- Cutting Edge: Tissue Antigen Expression Levels Fine-Tune T Cell Differentiation Decisions In Vivo.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Generation and Regeneration of Thymic Epithelial Cells.Frontiers in immunology · 2020Review
- Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression ofJournal of immunology (Baltimore, Md. : 1950) · 2019Article
- T-cell egress from the thymus: Should I stay or should I go?Journal of leukocyte biology · 2018Review
- Aire controls the recirculation of murine Foxp3European journal of immunology · 2018Article
- Twenty Years of AIRE.Frontiers in immunology · 2018Review
- Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality.Frontiers in immunology · 2018Article
- Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases.F1000Research · 2018Review
- HEB is required for the specification of fetal IL-17-producing γδ T cells.Nature communications · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The organization of the thymus into distinct cortical and medullary regions enables it to control the step-wise migration and development of immature T-cell precursors. Such a process provides access to specialized cortical and medullary thymic epithelial cells at defined stages of maturation, ensuring the generation of self-tolerant and MHC-restricted conventional CD4(+) and CD8(+) αβ T cells. The migratory cues and stromal cell requirements that regulate the development of conventional αβ T cells have been well studied. However, the thymus also fosters the generation of several immunoregulatory T-cell populations that form key components of both innate and adaptive immune responses. These include Foxp3(+) natural regulatory T cells, invariant γδ T cells, and CD1d-restricted invariant natural killer T cells (iNKT cells). While less is known about the intrathymic requirements of these nonconventional T cells, recent studies have highlighted the importance of the thymus medulla in their development. Here, we review recent findings on the mechanisms controlling the intrathymic migration of distinct T-cell subsets, and relate this to knowledge of the microenvironmental requirements of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.