ArticlePloS one2015
Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Meta-Analysis for the Association between Polymorphisms in Interleukin-17A and Risk of Coronary Artery Disease.International journal of environmental research and public health · 2016Pooled it
- Genetic Variants in CytokinesLife (Basel, Switzerland) · 2025Article
- A Common Genetic Background for Psoriasis and Cardiovascular Diseases: A Narrative Review.Health science reports · 2025Article
- Sister haplotypes and recombination disequilibrium: a new approach to identify associations of haplotypes with complex diseases.Frontiers in genetics · 2023Article
- Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants.Genes & diseases · 2022Review
- Article
- Association study between rs2275913 genetic polymorphism and serum levels of IL-17A with risk of coronary artery disease.Molecular biology research communications · 2020Article
- Plasma CXCL1 levels and TRAF3IP2 variants in patients with myocardial infarction.Journal of clinical laboratory analysis · 2018Article
- Influence ofMediators of inflammation · 2018Article
- Article
- The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke.Oncotarget · 2017Article
- Mechanistic rationales for targeting interleukin-17A in spondyloarthritis.Arthritis research & therapy · 2017Review
- Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease.Experimental and therapeutic medicine · 2017Article
- [Relationship between interleukin-17A gene polymorphisms and the susceptibility to childhood asthma].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Common variants in IL-17A/IL-17RA axis contribute to predisposition to and progression of congestive heart failure.Medicine · 2016Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe role of interleukin 17A (IL-17A) in the inflammatory process has caused interest in the potential significance of IL-17A as a biomarker for coronary artery disease (CAD). The aim of the present study was to evaluate the role of IL-17A gene polymorphisms as susceptibility markers for CAD in the Mexican population.
methodsFour IL-17A gene polymorphisms (rs8193036, rs3819024, rs2275913 and rs8193037) were genotyped by 5' exonuclease TaqMan assays in a group of 900 patients with premature CAD and 667 healthy controls (with negative calcium score by computed tomography), seeking associations with CAD and other metabolic and cardiovascular risk factors using logistic regression analyses.
resultsNo single IL-17A polymorphism was associated with premature CAD, however two haplotypes (CAGG and TAGA) were significantly associated with increased risk of premature CAD (OR = 1.35, 95% CI: 1.00-1.84, P = 0.018 and OR = 2.09, 95% CI: 1.16-3.76, P = 0.003, respectively). Moreover, rs3819024 was associated with increased levels of visceral abdominal fat (P = 0.002) and rs8193036 was significantly associated with risk of central obesity (P = 0.020), hypertriglyceridemia (P = 0.027), and metabolic syndrome (P = 0.027) in the premature CAD group, under dominant models adjusted by age, gender, BMI, smoking history, alcohol consumption, and treatment.
conclusionThe results suggest that IL-17A haplotypes are involved in the risk of developing premature CAD and some IL-17A polymorphisms are associated with cardiovascular risk factors in Mexican individuals with premature CAD.
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