ArticleThe American journal of psychiatry2015
Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study.
Article in The American journal of psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The brain on the beat: How music may heal schizophrenia.Schizophrenia research · 2023Article
- Deep psychophysiological phenotyping of adolescents and adults with 22q11.2 deletion syndrome: a multilevel approach to defining core disease processes.BMC psychiatry · 2023Article
- Evaluation of boundaries between mood and psychosis disorder using dynamic functional network connectivity (dFNC) via deep learning classification.Human brain mapping · 2023Article
- Psychotic Symptom, Mood, and Cognition-associated Multimodal MRI Reveal Shared Links to the Salience Network Within the Psychosis Spectrum Disorders.Schizophrenia bulletin · 2023Article
- Auditory Oddball Responses Across the Schizophrenia-Bipolar Spectrum and Their Relationship to Cognitive and Clinical Features.The American journal of psychiatry · 2021Article
- Heritability of Functional Connectivity in Resting State: Assessment of the Dynamic Mean, Dynamic Variance, and Static Connectivity across Networks.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Neurocognitive and neurophysiological endophenotypes in schizophrenia: An overview.Biomarkers in neuropsychiatry · 2020Article
- Relationship of prolonged acoustic startle latency to diagnosis and biotype in the bipolar-schizophrenia network on intermediate phenotypes (B-SNIP) cohort.Schizophrenia research · 2020Article
- Multisite Machine Learning Analysis Provides a Robust Structural Imaging Signature of Schizophrenia Detectable Across Diverse Patient Populations and Within Individuals.Schizophrenia bulletin · 2018Article
- Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science.BMC psychiatry · 2018Article
- EEG coherence related to fMRI resting state synchrony in long-term abstinent alcoholics.NeuroImage. Clinical · 2018Article
- Neurocognitive subtypes in patients with bipolar disorder and their unaffected siblings.Psychological medicine · 2017Article
- Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.Translational psychiatry · 2017Article
- Polygenic risk for type 2 diabetes mellitus among individuals with psychosis and their relatives.Journal of psychiatric research · 2016Article
- Multivariate Genetic Correlates of the Auditory Paired Stimuli-Based P2 Event-Related Potential in the Psychosis Dimension From the BSNIP Study.Schizophrenia bulletin · 2016Article
- Biomarkers in Psychiatry - A Critique.Annals of neurosciences · 2016Article
- Brain oscillations in bipolar disorder and lithium-induced changes.Neuropsychiatric disease and treatment · 2016Review
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Authors and funding
15 authors.
Funding
Abstract
objectiveBiological risk factors underlying psychosis are poorly understood. Biological underpinnings of the dimension of psychosis can be derived using genetic associations with intermediate phenotypes such as subcomponents of auditory event-related potentials (ERPs). Various ERP subcomponent abnormalities in schizophrenia and psychotic bipolar disorder are heritable and are expressed in unaffected relatives, although studies investigating genetic contributions to ERP abnormalities are limited. The authors used a novel parallel independent component analysis (para-ICA) to determine which empirically derived gene clusters are associated with data-driven ERP subcomponents, assuming a complex etiology underlying psychosis.
methodThe authors examined the multivariate polygenic association of ERP subcomponents from 64-channel auditory oddball data in 144 individuals with schizophrenia, 210 psychotic bipolar disorder probands, and 95 healthy individuals from the multisite Bipolar-Schizophrenia Network on Intermediate Phenotypes study. Data were reduced by principal components analysis to two target and one standard ERP waveforms. Multivariate association of compressed ERP waveforms with a set of 20,329 single-nucleotide polymorphisms (SNPs) (reduced from a 1-million-SNP array) was examined using para-ICA. Genes associated with SNPs were further examined using pathway analysis tools.
resultsPara-ICA identified four ERP components that were significantly correlated with three genetic components. Enrichment analysis revealed complement immune response pathway and multiple processes that significantly mediate ERP abnormalities in psychosis, including synaptic cell adhesion, axon guidance, and neurogenesis.
conclusionsThis study identified three genetic components comprising multiple genes mediating ERP subcomponent abnormalities in schizophrenia and psychotic bipolar disorder. The data suggest a possible polygenic structure comprising genes influencing key neurodevelopmental processes, neural circuitry, and brain function mediating biological pathways plausibly associated with psychosis.
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