Evidence map›Paper›PMID 25615523›Full record

Trial reportJournal of anxiety disorders2015

The impact of alcohol use severity on anxiety treatment outcomes in a large effectiveness trial in primary care.

Kate Wolitzky-Taylor, Lily A Brown, Peter Roy-Byrne, Cathy Sherbourne, Murray B Stein, Greer Sullivan, Alexander Bystritsky, Michelle G Craske

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of anxiety disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Impact of anxiety symptoms and problematic alcohol use on error-related brain activity.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kate Wolitzky-TaylorDepartment of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, United States.
Lily A BrownDepartment of Psychology, University of California, Los Angeles, United States.
Peter Roy-ByrneCenter for Healthcare Improvement for Addictions, Mental Illness, and Medically Vulnerable Populations (CHAMMP), University of Washington at Harborview Medical Center, United States.
Cathy SherbourneRAND Corporation, Santa Monica, CA, United States.
Murray B SteinDepartment of Psychiatry and Department of Family & Preventive Medicine, University of California, San Diego, United States.
Greer SullivanSouth Central VA Mental Illness Research Education and Clinical Center, North Little Rock, AK, United States; University of Arkansas for Medical Sciences, United States.
Alexander BystritskyDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, United States.
Michelle G CraskeDepartment of Psychology, University of California, Los Angeles, United States. Electronic address: craske@psych.ucla.edu.

Funding

CALM: Improving Primary Care Anxiety OutcomesU01MH057835 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEIN, MURRAY B. · 2005 to 2009
$3.3M
CALM: IMPROVING PRIMARY CARE ANXIETY OUTCOMESU01MH070018 · NIMH · RAND CORPORATION · PI SHERBOURNE, CATHY D · 2005 to 2009
$3.1M
CALM: Improving Primary Care Anxiety OutcomesU01MH058915 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRASKE, MICHELLE G · 2005 to 2009
$3.0M
CALM: Improving Primary Care OutcomesU01MH057858 · NIMH · UNIVERSITY OF WASHINGTON · PI ROY-BYRNE, PETER PAUL · 2005 to 2009
$2.4M
CALM: Improving Primary Care Anxiety OutcomesU01MH070022 · NIMH · UNIV OF ARKANSAS FOR MED SCIS · PI SULLIVAN, JAN GREER · 2005 to 2009
$2.3M
Improving Patient Outcomes in Anxiety DisordersK24MH064122 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEIN, MURRAY B. · 2001 to 2011
$1.3M
Treating Anxiety in Public Sector Medical SettingsK24MH065324 · NIMH · UNIVERSITY OF WASHINGTON · PI ROY-BYRNE, PETER PAUL · 2003 to 2007
$661k
NIMH NIH HHS K24 MH064122NIMH NIH HHS K24 MH065324NIMH NIH HHS U01 MH057835NIMH NIH HHS U01 MH057858NIMH NIH HHS U01 MH058915NIMH NIH HHS U01 MH070018NIMH NIH HHS U01 MH070022
6 · The paper itself

Abstract

objectiveThe presence of anxiety disorders is associated with poorer alcohol use disorder treatment outcomes, but little is known about the impact of alcohol use problems on anxiety disorder treatment outcomes despite their high comorbidity. The current study examined the impact of alcohol use symptom severity on anxiety disorder treatment outcomes in a multi-site primary care effectiveness study of anxiety disorder treatment.

methodData came from the Coordinated Anxiety Learning and Management (CALM) effectiveness trial. Participants (N=1004) were randomized to an evidence-based anxiety intervention (including cognitive behavioral therapy and medications) or usual care in primary care. Participants completed measures of alcohol use, anxiety, and depression at baseline, 6-, 12-, and 18-month follow-up periods. Patients with alcohol dependence were excluded.

resultsThere were no significant moderating (Treatment Group × Alcohol Use Severity) interactions. The majority of analyses revealed no predictive effects of alcohol use severity on outcome; however, alcohol problems at baseline were associated with somewhat higher anxiety and depression symptoms at the 18-month follow-up.

conclusionsThese data indicate that patients with alcohol problems in primary care can be effectively treated for anxiety disorders. Baseline alcohol problems were associated with some poorer long-term outcomes, but this was evident across CALM and usual care. These findings provide preliminary evidence that there may be no need to postpone treatment of anxiety disorders until alcohol problems are addressed, at least among those who have mild to moderate alcohol problems. Replication with more severe alcohol use disorders is needed.

Indexed as

AdultAlcohol DrinkingAlcohol-Related DisordersAnti-Anxiety AgentsAnxiety DisordersCognitive Behavioral TherapyCombined Modality TherapyDepressive DisorderFemaleHumansMalePrimary Health CareTreatment OutcomeAnti-Anxiety AgentsAlcohol useAnxiety disordersPredictors of treatment outcome

Identifiers

PMID25615523
PMCPMC4355176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.