ArticleCase reports in neurological medicine2014
Varicella Zoster Virus Meningitis in a Young Immunocompetent Adult without Rash: A Misleading Clinical Presentation.
Article in Case reports in neurological medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Varicella-zoster virus meningitis with hypoglycorrhachia: A case report.World journal of clinical cases · 2023Article
- Clinical features of varicella-zoster virus caused neurological diseases detected by metagenomic next-generation sequencing.Open medicine (Warsaw, Poland) · 2023Article
- Varicella zoster meningitis in a pregnant woman with uncontrolled type 1 diabetes mellitus.BMJ case reports · 2021Article
- Varicella Zoster Meningitis with Hypoglycorrhachia on Cerebrospinal Fluid (CSF) Analysis in a Young Immunocompetent Host without a Rash.The American journal of case reports · 2019Article
- Varicella zoster virus infections in neurological patients: a clinical study.BMC infectious diseases · 2018Article
- Varicella zoster meningitis: an atypical case of zoster reactivation in immunocompetent young adult.BMJ case reports · 2018Article
- Varicella Zoster aseptic meningitis: Report of an atypical case in an immunocompetent patient treated with oral valacyclovir.IDCases · 2018Article
- Article
- Clinical benefits of routine varicella vaccination for adults.Human vaccines & immunotherapeutics · 2015Article
- Unusual Presentation ofAnnals of Indian Academy of NeurologyArticle
- Meningitis with polymerase chain reaction for varicella zoster positivity in cerebrospinal flid of a young immunocompetent adult.Journal of neurosciences in rural practiceArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meningitis caused by varicella zoster virus (VZV) is rare in healthy population. Predominantly immunocompromised patients are affected by reactivation of this virus with primary clinical features of rash and neurological symptoms. Here we report a young otherwise healthy man diagnosed with a VZV meningitis without rash. He complained of acute headache, nausea, and vomiting. The clinical examination did not show any neurological deficits or rash. Cerebrospinal fluid (CSF) analysis revealed a high leukocyte cell count of 1720 cells/µL and an elevated total protein of 1460 mg/L misleadingly indicating a bacterial infection. Further CSF analyses, including polymerase chain reaction (PCR) and detection of intrathecal synthesis of antibodies, showed a VZV infection. Clinical and CSF follow-up examinations proved the successful antiviral treatment. In conclusion, even young immunocompetent patients without rash might present with VZV meningitis. CSF examination is a key procedure in the diagnosis of CNS infections but in rare cases the standard values cell count and total protein might misleadingly indicate a bacterial infection. Thus, virological analyses should be considered even when a bacterial infection is suspected.
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