ArticleThe open rheumatology journal2014
Felty's Syndrome, Insights and Updates.
Article in The open rheumatology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Novel genetic insights: Mendelian randomization implicates Felty Syndrome in atrial fibrillation risk.Clinical rheumatology · 2026Article
- mFABIO: An integrative multi-tissue TWAS fine-mapping approach to prioritize potentially causal genes and tissues underlying binary traits.PLoS genetics · 2026Article
- Non-linear association of admission platelet-to-lymphocyte ratio with 28- and 90-day mortality in critically ill patients with rheumatoid arthritis: a retrospective cohort study.Clinical rheumatology · 2026Article
- Case Report: Immunotherapy-induced Felty syndrome in a patient with metastatic melanoma.Frontiers in oncology · 2026Article
- Development and Validation of a Cost-Effective Machine Learning Model for Screening Potential Rheumatoid Arthritis in Primary Healthcare Clinics.Journal of inflammation research · 2025Article
- Emergencies in inflammatory rheumatic diseases.Rheumatology international · 2024Review
- Felty Syndrome in a Patient Presenting With Bilateral Scleritis and Multiple Autoimmune Syndrome: A Case Report.Cureus · 2024Article
- Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment.Journal of personalized medicine · 2023Review
- Article
- T-cell Large Granular Lymphocytic Leukemia and Felty Syndrome in Rheumatoid Arthritis: A Case Report.Cureus · 2023Article
- Biological treatment in Felty's syndrome with profound neutropenia.Reumatologia · 2023Article
- Severe alveolar bone resorption in Felty syndrome: a case report.Journal of medical case reports · 2022Article
- The Diagnosis Felt(y) Right: A Case Report of Felty Syndrome With Limited Articular Involvement.Cureus · 2022Article
- Article
- Non-Articular Felty Syndrome Refractory to Granulocyte Colony-Stimulating Factor Therapy.Cureus · 2021Article
- Article
- Felty syndrome: a case report.Journal of medical case reports · 2021Article
- Splenomegaly in Children and Adolescents.Frontiers in pediatrics · 2021Review
- Phenotypic variability in a child with Felty's syndrome: a case report.BMC pediatrics · 2020Article
- Porto-Sinusoidal Vascular Disease as the Cause of Portal Hypertension in Felty's Syndrome: A Case Report and Literature Review.BioMed research international · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Felty's syndrome (FS) is characterized by the triad of seropositive rheumatoid arthritis (RA) with destructive joint involvement, splenomegaly and neutropenia. Current data shows that 1-3 % of RA patients are complicated with FS with an estimated prevalence of 10 per 100,000 populations. The complete triad is not an absolute requirement, but persistent neutropenia with an absolute neutrophil count (ANC) generally less than 1500/mm3 is necessary for establishing the diagnosis. Felty's syndrome may be asymptomatic but serious local or systemic infections may be the first clue to the diagnosis. FS is easily overlooked by parallel diagnoses of Sjӧgren syndrome or systemic lupus erythematosus or lymphohematopoietic malignancies. The role of genetic (HLA DR4) is more prominent in FS in comparison to classic rheumatoid arthritis. There is large body of evidence that in FS patients, both cellular and humoral immune systems participate in neutrophil activation, and apoptosis and its adherence to endothelial cells in the spleen. It has been demonstrated that proinflammatory cytokines may have inhibitory effects on bone marrow granulopoiesis. Binding of IgGs to neutrophil extracellular chromatin traps (NET) leading to neutrophil death plays a crucial role in its pathophysiology. In turn, "Netting" neutrophils may activate auto-reactive B cells leading to further antibody and immune complex formation. In this review we discuss on basic pathophysiology, epidemiology, genetics, clinical, laboratory and treatment updates of Felty's syndrome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.